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Composition containing fructus aurantii immaturus for treating cardiovascular diseases and its preparation

A technology of composition and preparation, which is applied in the field of compositions and preparations containing citrus aurantium for treating cardiovascular diseases, and can solve problems such as difficulty in preparing drop pills

Inactive Publication Date: 2007-12-12
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the strict requirements of the drop pill preparation process on the matrix excipients, it is often difficult to prepare drop pills that meet the quality requirements after replacing the matrix excipients. Therefore, finding a suitable matrix excipient to replace the current polyethylene glycol has become a constant effort of medical personnel. direction

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] The raw materials are 97g of Salvia miltiorrhiza, 79g of notoginseng, 35g of citrus aurantium, 3g of balsamic oil, and 40g of ginseng

[0068] Salvia miltiorrhiza, notoginseng, citrus aurantium and ginseng with 5 times the amount of water, decoct for 2 hours, filter, and extract the residue for the second time, add 4 times the amount of water, fry for 1 hour, filter, discard the filter residue, and open the filtrate . The filtrate is concentrated under reduced pressure to a ratio of 1: 0.9 to 1.1 between the volume of the medicinal solution (L) and the weight (Kg) of the medicinal material, adding ethanol to make the alcohol concentration of the medicinal solution at 70%, leaving it to stand, filtering, and concentrating the filtrate to obtain a relative density of 1.32 ~1.40 (55°C) extract. Add balsamic oil, dry, make granules, compress into tablets, or coat with sugar, that is to say.

Embodiment 2

[0070] Danshen 100g, Panax notoginseng 10g, Citrus aurantium 15g;

[0071] Salvia miltiorrhiza, notoginseng, and orange are extracted with 70% ethanol, and the extract is micro-filtered with a ceramic membrane to collect the filtrate; The outlet pressure is 0.20kPa lower than the inlet pressure. In the initial stage of ultrafiltration, a lower pressure is used, and then the pressure is gradually increased; in the process of ultrafiltration, periodic pressure fluctuations are adopted, and the pressure fluctuation difference is 0.2Mpa. The flow rate of the feed liquid is 3.0m / s. During the ultrafiltration process, periodic flow fluctuations are used to generate pulsating or unstable flows in the membrane channel. The difference in flow rate fluctuations is 2.0m / s. Nitrogen is intermittently fed into the ultrafiltration system , to form a gas-liquid pulse flow, and the period is 2h to ventilate once, each time for 1 minute. The temperature of the feed liquid is 40°C. When the o...

Embodiment 3

[0074] The raw materials are 20g of salvia miltiorrhiza, 2g of notoginseng, 10g of citrus aurantium, 100g of angelica, and 2.2g of borneol.

[0075] Add 5 times the amount of water to Danshen, Panax notoginseng, Citrus aurantium and Angelica, decoct for 2 hours, filter, and extract the filter residue for the second time, add 4 times the amount of water, fry for 1 hour, filter, discard the filter residue, and combine the filtrate. The filtrate is concentrated under reduced pressure to a ratio of 1: 0.9 to 1.1 between the volume of the medicinal solution (L) and the weight (Kg) of the medicinal material, adding ethanol to make the alcohol concentration of the medicinal solution at 70%, leaving it to stand, filtering, and concentrating the filtrate to obtain a relative density of 1.32 ~1.40 (55°C) extract. The extract and borneol are fluidized with lactose in a batch fluidized bed, dried, and made into granules.

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Abstract

The invention discloses a Chinese medicinal composition for treating cardiovascular diseases, which is prepared mainly from root of red rooted saliva, notoginseng, trifoliate orange, Chinese angelica root, motherwort, astragalus root, ginseng or Codonopsis pilosula, any one of the compositions may also comprise baras camphor, rosewood oil, liquidambar orientalis mill, musk or musk ketone. The invention also discloses preparations using any one of the medicinal compositions as the effective constituents, preferably drop pills. The auxiliary materials of the drop pill substrate can be polyethylene glycol or natural materials, especially those of plant sources. The medicament has quick effect and good therapeutic action for coronary disease and angina pectoris.

Description

technical field [0001] The present invention relates to a kind of medicinal composition and its preparation containing Fructus Fructus Citrus Fructus for treating cardiovascular diseases, in particular to a kind of medicinal composition for treating cardiovascular diseases which is made from traditional Chinese medicinal materials. Background technique [0002] According to my country's epidemiological survey, the incidence and mortality of cardiovascular and cerebrovascular diseases have been on the rise in the past 50 years, whether in rural areas or cities. In the 1950s and 1960s, cardiovascular disease and cerebrovascular disease ranked fifth and sixth respectively among the causes of death in my country, and rose to second and third respectively after 1970. Cardiovascular and cerebrovascular diseases accounted for the first of all causes of death. In my country, the proportion of deaths due to cardiovascular and cerebrovascular diseases to the total death population has...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61K9/20A61K47/36A61P9/10A61K35/55A61K31/122A61K31/045
Inventor 李旭郑永锋李永强
Owner TIANJIN TASLY PHARMA CO LTD
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