Paederia extractive and medical use of the same

A kind of extract, the technology of chicken dung vine, which is applied in the field of chicken dung rattan extract, can solve the problems of poor analgesic effect and unstable effect, and achieve excellent anti-inflammatory and analgesic effects without addiction

Active Publication Date: 2008-02-27
SUZHOU YI HUA BIOMEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present inventors have found that the Rubiaceae plant Caulis chinensis has analgesic function, but simply using the medicin

Method used

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  • Paederia extractive and medical use of the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1 prepares the extract of chicken dung vine

[0028] 1. 1 kg of washed and broken whole herb of Caulis chinensis was reflux extracted with 70% ethanol solution for 2 hours, collected the ethanol solution and concentrated it to dryness under reduced pressure to obtain 90 grams of extract;

[0029] 2. Dissolve the extract obtained in step 1 with 2 liters of ethanol solution with a volume concentration of 10% at a temperature of 45° C., then centrifuge the resulting solution and get the supernatant;

[0030] 3. the gained supernatant is passed through the macroporous adsorption resin chromatography column, and the weight of the macroporous adsorbent resin is 20 times of the obtained extract weight;

[0031] 4. Wash the macroporous adsorption resin column with a volume concentration of 20% ethanol solution until the color of the solution becomes light. The amount of ethanol used is 10 times the volume of the macroporous adsorption resin column; its flow rate is ...

Embodiment 2

[0035] Embodiment 2 prepares the extract of chicken dung vine

[0036] Repeat the extraction steps of Example 1, but the ethanol concentration of the original step 1, the concentration of the ethanol solution used to dissolve the medicinal extract of the step 2, the amount of the macroporous adsorption resin of the step 3, the amount of the macroporous adsorption resin used for the washing and adsorption of the steps 4 and 5 The concentration of the ethanol solution of column and consumption and the flow velocity when washing column thereof are changed to respectively: 90%; 5%; 30 times; 25%; 8 times; 70%; 15 times; 1.5;); The weight of the extract of gained It is 11g, and the content of gallizine and gallizine in the extract is 20% and 70%, respectively.

Embodiment 3

[0037] Embodiment 3 prepares the extract of chicken dung vine

[0038] Repeat the extraction steps of Example 1, but the ethanol concentration of the original step 1, the concentration of the ethanol solution used to dissolve the medicinal extract of the step 2, the amount of the macroporous adsorption resin of the step 3, the amount of the macroporous adsorption resin used for the washing and adsorption of the steps 4 and 5 The concentration of the ethanol solution of column and consumption and the flow velocity when washing column thereof are changed into respectively: (50%; 3%; 35 times; 15%; 12 times; 80%; 20 times; 2); The weight of the extract of gained It is 12g, and the content of gallizine and gallizine in the extract is 65% and 20%, respectively.

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PUM

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Abstract

The invention discloses an alcohol extractable matter of paederia scandens of Rubiaceae plant, which is characterized by the following: extracting iridoid glycosides compound as effective component; displaying obvious analgesic and anti-inflammatory action when the content of paederia scandensin and paederia scandensin acid methyl ester at 10-90% respectively; improving the analgesic and anti-inflammatory action when the content of paederia scandensin and paederia scandensin acid methyl ester at 20-60% respectively; displaying the best analgesic and anti-inflammatory action when the content rate of paederia scandensin and paederia scandensin acid methyl ester at 5: 1-1: 5. The invention has similar analgesic action to opium drug without habituation.

Description

technical field [0001] The present invention relates to extracts of chicken dung vine. The invention also relates to the medical use of the extract. Background technique [0002] According to the data of SFDA Southern Medical Economic Research Institute, there are three categories of painkillers currently in clinical use. One is non-steroidal anti-inflammatory painkillers represented by aspirin, which includes ibuprofen, indomethacin, rofecoxib, celecoxib, etc. Non-steroidal anti-inflammatory analgesics are widely used with definite curative effect, good analgesic effect on general pain and non-addictive, but improper use can lead to gastrointestinal toxicity and upper gastrointestinal bleeding; long-term improper use can also lead to heart disease. Vascular damage; this analgesic has adverse effects on hematopoiesis, leading to aplastic anemia. In addition, long-term use of such drugs can damage liver and kidney functions. [0003] The second is opioid painkillers. Alt...

Claims

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Application Information

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IPC IPC(8): A61K36/74A61P29/00
Inventor 蒋毅王永兵
Owner SUZHOU YI HUA BIOMEDICAL TECH CO LTD
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