Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Aquilaria sinensis leaf extract as well as preparation method and application thereof

The technology of the leaves and extracts of A. chinensis, which is applied in the direction of drug combinations, pharmaceutical formulas, and medical preparations containing active ingredients, can solve the problems of toxic and side effects of the body, and achieve simple preparation methods, excellent anti-inflammatory activity, and good anti-inflammation Analgesic effect

Active Publication Date: 2015-04-29
DONGGUAN MATHEMATICAL ENG ACAD OF CHINESE MEDICINE GUANGZHOU UNIV OF CHINESE MEDICINE
View PDF1 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antibiotics are the main treatment for inflammation in modern clinics, but most antibiotics have obvious toxic and side effects on the body while treating diseases

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Aquilaria sinensis leaf extract as well as preparation method and application thereof
  • Aquilaria sinensis leaf extract as well as preparation method and application thereof
  • Aquilaria sinensis leaf extract as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Weigh 1 kg of dry Akiras sinensis leaf powder and place them in a round-bottomed flask, add 10 times the amount of 70% ethanol, reflux 3 times, 1 hour each time, filter, combine the filtrate, and concentrate the filtrate until it has no alcohol smell; pass through AB- 8 macroporous resin columns, control the flow rate to 2BV / h, first use 5 times the column volume (5BV) of water to elute the macroporous resin to remove impurities; then use 3 times the column volume (60% ethanol) to elute the macroporous resin, collect Concentrate and dry the part eluted with ethanol to obtain the extract of Akiras sinensis leaves.

[0026] After testing, the extract contains 6% of 2-O-a-rhamnoside-4,6,4'.-trihydroxybenzophenone, 5% of 3-C-glucoside-2,4,6, 4'.-tetrahydroxybenzophenone, 40% mangiferin, 6% 3.5-C-glucoside-2,4,6,4'.-tetrahydroxybenzophenone, 14% 5,4 -Dimethoxy-7-hydroxyflavone, 13% acetin-7,4'-dimethyl ether.

[0027] The detection method of above-mentioned each compositio...

Embodiment 2

[0031] Weigh 1 kg of dry Akiras sinensis leaf powder and place them in a round-bottomed flask, add 10 times the amount of 70% ethanol, reflux 3 times, 1 hour each time, filter, combine the filtrate, and concentrate the filtrate until it has no alcohol smell; pass through AB- 8 macroporous resin columns, control the flow rate to 2BV / h, first use 5 times the column volume (5BV) of water to elute the macroporous resin to remove impurities; then use 3 times the column volume of 50% ethanol to elute the macroporous resin, collect Concentrate and dry the part eluted with ethanol to obtain the extract of Akiras sinensis leaves.

[0032] After testing (the detection method is the same as in Example 1), the extract contains 8% of 2-O-a-rhamnoside-4,6,4'.-trihydroxybenzophenone, 10% of 3-C-glucose Glycoside-2,4,6,4'.-tetrahydroxybenzophenone, 45% mangiferin, 8% 3.5-C-glucoside-2,4,6,4'.-tetrahydroxybenzophenone Ketone, 12% 5,4-dimethoxy-7-hydroxyflavone, 10% apigenin-7,4'-dimethyl ethe...

Embodiment 3

[0034] Weigh 1 kg of dry Akiras sinensis leaf powder and place them in a round-bottomed flask, add 10 times the amount of 70% ethanol, reflux 3 times, 1 hour each time, filter, combine the filtrate, and concentrate the filtrate until it has no alcohol smell; pass through AB- 8 macroporous resin columns, control the flow rate to 2BV / h, first use 5 times the column volume (5BV) of water to elute the macroporous resin to remove impurities; then use 3 times the column volume (40% ethanol) to elute the macroporous resin, collect Concentrate and dry the part eluted with ethanol to obtain the extract of Akiras sinensis leaves.

[0035] After testing (the detection method is the same as in Example 1), the extract contains 10% of 2-O-a-rhamnoside-4,6,4'.-trihydroxybenzophenone, 12% of 3-C-glucose Glycoside-2,4,6,4'.-tetrahydroxybenzophenone, 52% mangiferin, 9% 3.5-C-glucoside-2,4,6,4'.-tetrahydroxybenzophenone Ketones, 4% 5,4-dimethoxy-7-hydroxyflavone, 6% apigenin-7,4'-dimethyl ether...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the field of traditional Chinese medicine extraction, and particularly discloses an aquilaria sinensis leaf extract as well as a preparation method and an application thereof. The extract comprises the following six components: 2-O-a-rhamnoside-4,6,4'-trihydroxybenzo phenone, 3-C-heteroside-2,4,6,4'-tetrahydroxybenzophenone, mangiferin, 3.5-C-glucoside-2,4,6,4'-trihydroxybenzo phenone, 5,4-dimethoxy-7-hydroxy flavone and apione-7,4'-dimethyl ether. The aquilaria sinensis leaf extract has good anti-inflammatory and analgesic effects and can be used for preparing anti-inflammatory and analgesic drugs; and the effective constituents in the extract are clear so that benefit is brought to the medication safety.

Description

technical field [0001] The invention relates to the field of extraction of traditional Chinese medicines, in particular to an extract of arborina japonica leaves and a preparation method and application thereof. Background technique [0002] White wood incense is commonly called earth agarwood, and it is mainly produced in Southeast Asian countries such as India and Malaysia. Rich in the Lingnan area of ​​my country, it is a rare and precious Chinese medicinal material with a long history in my country, and is also an important "Southern Medicine" resource. It ranks among the "Top Ten Southern Medicines". Aquilaria sinensis (Lour.) Gilg.] The resinous part of the heartwood. In modern clinics, it is often used in the treatment of various diseases mainly involving the digestive system, nervous system and cardiovascular system, and has good results. All editions of the "Chinese Pharmacopoeia" have recorded agarwood, and since the 2010 edition of the Pharmacopoeia, agarwood ha...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P29/00A61K31/7034A61K31/351A61K31/352
CPCA61K31/351A61K31/352A61K31/7034A61K31/7048A61K2300/00
Inventor 易智彪肖炜华曾宝谢友良马麟王环詹丽玲陈志维赖小平
Owner DONGGUAN MATHEMATICAL ENG ACAD OF CHINESE MEDICINE GUANGZHOU UNIV OF CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com