Spectroscopic determination of analyte concentration
An analyte and spectroscopic technology, applied in the field of spectroscopy, can solve the problems of limited reproducibility, complex detection, Raman signal interference, etc., to achieve the effect of improving sensitivity, improving accuracy, and reducing Raman signal interference
Inactive Publication Date: 2010-12-08
KONINK PHILIPS ELECTRONICS NV
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[0005] At the same time, most of the various Raman signals may face interference, which further complicates the detection of specific analytes or components of body fluids such as blood
Therefore, the dependence of the obtained spectral signal on the morphology or consistency of the biological tissue undergoing spectral analysis will limit the reproducibility of analyte concentration determination
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[0068] figure 1 A schematic block diagram of the spectroscopic device and its main components is shown. The spectroscopic device 100 has a radiation source 118 , an optical coupling device 110 , a focusing lens 112 , an imaging system 114 , a spectroscopic analysis unit 116 and a control unit 120 . In an exemplary embodiment, spectroscopic device 100 may be applied to skin tissue such as a human patient. The tissue or body part of a human patient contains blood vessels 104 underlying the epidermis 102 . Blood vessel 104 is characterized by a vessel wall 108 that is highly permeable to the analyte, such as blood glucose, whose concentration is to be determined.
[0069] The shape and size of the blood vessel 104 designate the first space, the location and structure of which is determined by the imaging system 114 . Preferably, imaging and spectral analysis are accomplished by utilizing a common objective lens 112 . Even though both imaging and spectroscopic analysis can uti...
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A spectroscopic apparatus, a method of determining a concentration and / or spatial gradient of an analyte of a bodily fluid and a corresponding computer program product are provided. The spectroscopic apparatus provides determination of a position of a capillary vessel (104) within a biological sample in order to focus spectroscopic excitation radiation to a volume (122) . that is in close proximity to the capillary vessel but does not overlap with the capillary vessel. The provided apparatus, method, and computer program product advantageously exploit the permeability of the vessel wall with respect to an analyte that is subject to analyte concentration determination. By means of biological transport processes, the concentration of an analyte of a bodily fluid located in the capillary vessel influences the concentration in the surrounding of the capillary vessel. Spectroscopic analysis of a volume outside the capillary vessel can therefore serve for a precise and reliable analyte concentration determination inside the capillary vessel .
Description
technical field [0001] The present invention relates to the field of spectroscopy, and more specifically, is not limited to non-invasive analyte concentration determination using optical imaging and spectroscopic techniques. Background technique [0002] Also, it is known from the prior art to use optical spectroscopic techniques for analytical purposes. WO 02 / 057758 A1 and WO 02 / 057759 A1 describe spectroscopic analysis devices for non-invasive in vivo spectroscopic analysis of blood components flowing through the capillaries of a patient. In order to identify the region of interest, the position of the capillaries is determined by the imaging system, wherein the excitation beam for the spectroscopic analysis must be directed at the region of interest. [0003] Both imaging and spectroscopic analysis use a common focusing device that enables imaging of capillaries on one hand and allows focusing of near-infrared (NIR) laser beams within capillaries for excitation of Raman ...
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IPC IPC(8): A61B5/1455
CPCA61B5/489A61B5/14532
Inventor G·吕卡森R·德里森K·施密特G·普佩尔斯P·卡斯佩斯
Owner KONINK PHILIPS ELECTRONICS NV