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Chinese angelica and peony formula extraction, preparation and medical use thereof

An extract, the technology of Angelica peony root, applied in the field of Angelica peony root herbal extract, can solve the problems of inconvenient medication, unable to guarantee the effectiveness of clinical medication, large dosage and the like

Active Publication Date: 2008-04-30
INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In actual application, no matter it is used as decoction, pill, capsule or other dosage forms, there are obvious deficiencies in this prescription, which are mainly manifested in the following aspects: one is that the dosage is large, it is inconvenient to take medicine, and it is difficult to make a modern and convenient pharmaceutical dosage form. The second is that the active ingredients are not clear, and the active ingredients are not used as quality control indicators, so it is difficult to ensure the stability and controllability of product quality; the third is that when various reasons lead to large changes in the content of active ingredients in medicinal materials, there is no effective means to ensure The content of active ingredients in the product is stable, so the effectiveness of clinical medication cannot be guaranteed

Method used

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  • Chinese angelica and peony formula extraction, preparation and medical use thereof
  • Chinese angelica and peony formula extraction, preparation and medical use thereof
  • Chinese angelica and peony formula extraction, preparation and medical use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] Example 1: Preparation of DSS-A-N-30, an extract of Danggui Shaoyao Fang

[0079] The single herbs of Danggui Shaoyao Formula are prepared according to the common ratio, Angelica: Paeoniae: Poria cocos: Atractylodes macrocephala: Alisma: Chuanxiong (3:16:4:4:8:8) or after adding or subtracting part of the herbs to form a crude drug 1500 grams, add six times the weight of the crude drug in boiling water and decoct three times for 1.5 hours each time, filter, and concentrate under reduced pressure to an appropriate volume.

[0080] After dissolving in water, carry out HP-20 macroporous adsorption resin column chromatography, the ratio of resin column bed volume (ml) to sample amount (grams) is 5:1, then eluted with water and 30% ethanol in sequence, and eluted with 30% ethanol Parts were concentrated to remove alcohol and then freeze-dried to obtain DSS-A-N-30 (33.0 g) as a tan powder. It has the aforementioned qualitative response characteristics.

[0081] The content ...

Embodiment 2

[0082] Example 2: Preparation of DSS-A-N-30, an extract of Danggui Shaoyao Fang

[0083] The single herbs of Danggui Shaoyao Formula are prepared according to the common ratio, Angelica: Paeoniae: Poria cocos: Atractylodes macrocephala: Alisma: Chuanxiong (3:16:4:4:8:8) or after adding or subtracting part of the herbs to form a crude drug 1500 grams, add six times the weight of the crude drug in boiling water and decoct three times for 1.5 hours each time, filter, and concentrate under reduced pressure to an appropriate volume.

[0084] After dissolving in water, carry out HP-20 macroporous adsorption resin column chromatography, the ratio of resin column bed volume (ml) to sample amount (gram) is 5: 1, then elution with water and 40% ethanol in sequence, 40% ethanol elution Parts were concentrated to remove alcohol and then freeze-dried to obtain DSS-A-N-30 (35.0 g) as a tan powder. It has the aforementioned qualitative response characteristics.

[0085] The content of tota...

Embodiment 3

[0086] Example 3: Biological Activity Experiment of Danggui Shaoyao Prescription Extract

[0087] Unless otherwise stated, the DSS-A-N-30 used in Example 3 refers to the DSS-A-N-30 prepared in Example 1.

[0088] 1. Analgesic effect of DSS-A-N-30

[0089] 1. Effect of oral administration of DSS-A-N-30 on the number of writhing reactions in mice induced by acetic acid

[0090] Male Kunming mice, 22-26 g, were given the corresponding drug orally for 40 minutes, and then injected 0.6% acetic acid aqueous solution at a dose of 10 ml / kg intraperitoneally. After injecting the acetic acid solution for 5 minutes, observe and record the number of animal writhing within 15 minutes. The results showed that oral administration of DSS-A-N-30 could significantly reduce the number of writhing reactions in mice induced by acetic acid (Table 1).

[0091] Table 1. Effect of DSS-A-N-30 on the number of writhing reactions in mice induced by acetic acid

[0092]

[0093] Note: *P<0.05, **P<0...

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Abstract

A glycoside extract DSS-A-N-30 of an anoelica sinensis herbaceous peony prescription comprises an integral glycoside (herbaceous peony glycoside and white peony root glycoside) of 36.0-44.0 of the weight percentage calculated by the weight of the extract, wherein the anoelica sinensis herbaceous peony prescription comprises anoelica sinensis, herbaceous peony, poria cocos wolf, white atractylodes rhizome, rhizoma alismatis, and chuanxiong rhizome of which the weight proportion of the compatibility is 3:16:4:4:8:8. The products or the medicament compositions with the extract are used as the products or the medicament purposes for curing the diseases which are related with the ache, senescence, and hypofunction and disorder of reproductive endocrine, in particular to dysmenorrheal, unregulated menstrual flow, abortion, climacteric metancholia, senile dementia, hypofunction of ootheca and the like.

Description

technical field [0001] The present invention relates to the extract of Danggui Shaoyao Fang (hereinafter abbreviated as: DSS-A-N-30), its preparation method, the product or pharmaceutical composition containing the extract and its treatment related to pain, aging and reproductive endocrine dysfunction or disorder Products or medicines for various diseases (especially dysmenorrhea, irregular menstruation, miscarriage, menopausal syndrome, dementia, ovarian hypofunction, etc.). technical background [0002] Danggui Shaoyao Powder comes from "Synopsis of the Golden Chamber". The whole prescription is composed of 6 herbs: Angelica, Paeoniae, Poria, Atractylodes macrocephala, Alisma, and Chuanxiong. Banjin and Chuanxiong Banjin were originally designed to treat women's pregnancy diseases. [0003] Danggui Shaoyao Powder has a history of thousands of years of application. The prescription has experienced generations of development, and its composition, dosage, and functions and i...

Claims

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Application Information

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IPC IPC(8): A61K36/884A61P15/00A61P15/08A61P15/12A61P25/28
Inventor 乔善义周文霞马渊尚玮玮张永祥刘国云
Owner INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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