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Globeflower tablet and preparing technique thereof

A technology of nasturtium and tablet, which is applied in the direction of pill delivery, medical preparations containing active ingredients, plant raw materials, etc., which can solve the problems of low content of active ingredients, low content of total flavonoids of effective antibacterial ingredients, and insignificant drug efficacy, etc. , to achieve the effect of increased drug effect, good effect and remarkable curative effect

Inactive Publication Date: 2008-05-07
药都制药集团股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Simultaneously, when the water extract extracts active ingredients, it also extracts impurities such as a large amount of resin, mucus, starch, tannin, and the total flavonoid content of the effective antibacterial ingredients extracted is very low. There is low content of active ingredient in the formed Trollius tablet, and the defect of insignificant drug effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A. Precisely weigh 400 parts of nasturtium, crush the medicinal materials, extract twice with 30 times the amount of 50% ethanol, the extraction temperature is 100 ° C, each time for 2 hours, filter, and combine the extracts;

[0035] B. The extract is extracted 3 times with n-butanol, the upper organic phase is taken to obtain the n-butanol solution containing total flavonoids of Trollius chinensis, rotary evaporated at 45° C., 120 rpm, and evaporated to dryness to obtain the total flavonoids of N. Dried flavonoids;

[0036] C. Accurately weigh 400 parts of nasturtium, add 15 times of water for the first time, decoct for 100 minutes; add 12 times of water for the second time and decoct for 70 minutes to obtain the filtrate;

[0037] D. The n-butanol extracted total flavonoids of Nasturtium chinensis obtained in B is mixed with the filtrate in C, and then concentrated, and the concentrated solution is slowly added to the AB-8 macroporous adsorption resin chromatography ...

Embodiment 2

[0044]A. Accurately weigh 300 parts of nasturtium, crush the medicinal materials, extract twice with 25 times the amount of 50% ethanol, the extraction temperature is 100 ° C, 1.5 hours each time, filter, and combine the extracts;

[0045] B. The extract is extracted once with n-butanol, and the upper organic phase is taken to obtain the n-butanol liquid containing total flavonoids of Trollaceae, rotary evaporated at 45°C, 120 rpm, and evaporated to dryness to obtain the total flavonoids extracted with n-butanol. Dried flavonoids;

[0046] C. Accurately weigh 300 parts of nasturtium, add 10 times of water for the first time, decoct for 80 minutes; add 10 times of water for the second time and decoct for 50 minutes to obtain the filtrate;

[0047] D. The n-butanol extracted total flavonoids of Nasturtium chinensis obtained in B is mixed with the filtrate in C, and then concentrated, and the concentrated solution is slowly added to the AB-8 macroporous adsorption resin chromatog...

Embodiment 3

[0054] A. Accurately weigh 300-400 parts of nasturtium, crush the medicinal material, extract twice with 25-30 times the amount of 50% ethanol, the extraction temperature is 100 ° C, each time for 1.5-2 hours, filter, and combine the extracts;

[0055] B. The extract is extracted with n-butanol for 1-3 times, the upper organic phase is taken to obtain the n-butanol liquid containing the total flavonoids of Trollus chinensis, rotary evaporated at 45 ° C, 120 rpm, and evaporated to dryness to obtain n-butanol extracted gold Dried lotus total flavonoids;

[0056] C. Accurately weigh 300-400 parts of nasturtium, add 10-15 times of water for the first time, decoct for 80-100 minutes; add 10-12 times of water for the second time and decoct for 50-70 minutes to obtain the filtrate;

[0057] D. The n-butanol extracted total flavonoids of Nasturtium chinensis obtained in B is mixed with the filtrate in C, and then concentrated, and the concentrated solution is slowly added to the AB-8 ...

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Abstract

The invention discloses a Chinese globeflower tablet, which is composed by the following weight components: 20 to 40 parts of normal butyl alcohol extraction Chinese globeflower flavone dry substance, 30 to 50 parts of Chinese globeflower aqueous extract, 90 to 120 parts of bulking agent, 0 to 10 parts of corrective, 0.3 to 2 parts of lubricating agent and other auxiliary materials with proper amount. The invention also discloses the process of manufacturing the Chinese globeflower tablet. The method of utilizing alcohol to extract normal butyl alcohol extract and Chinese globeflower aqueous extract mixture not only improves the content of the Chinese globeflower total flavone of bacteriostasis component, but also keeps beneficial component held in Chinese globeflower, thereby the content of the total flavone including in the manufactured Chinese globeflower tablet is greatly improved, so as to lead the effect of medicine action to be increased and the curative effect to be obvious.

Description

technical field [0001] The invention relates to a traditional Chinese medicine tablet formula and a manufacturing process, in particular to a nasturtium tablet and a manufacturing process thereof. Background technique [0002] Nasturtium, also known as nasturtium, is the dried flower and bud of nasturtium of the Ranunculaceae plant. According to literature records, there are 25 species of plants in the genus Nasturtium, which are distributed in temperate and cold tropical alpine regions. There are more than 10 species in my country, and the medicinal nasturtium has wide petals, long and short petals. Distributed in Hebei, Shanxi, Inner Mongolia, and Northeast China. Among them, the flavonoid content of the medicinal materials produced in Chengde, Hebei Province is the best. See Bai Yuming's Chinese medicinal material Trollius "Chinese Herbal Medicine", Volume 25, Issue 6, Page 291, 1994 . The aqueous extract of Trollius chinensis has inhibitory effect on Gram-positive bacte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K9/20A61P31/04A61K133/00
Inventor 李晓恩
Owner 药都制药集团股份有限公司
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