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Portable fast joint inspection device for foetus teratogenic disease

A portable, fetal technology, which is applied in the field of medical devices and sample detection test strips, can solve the problems of insurmountable cross interference, high manufacturing cost, and inability to detect, so as to avoid the spread of pathogens, facilitate quality control, and avoid detection of cross interference.

Active Publication Date: 2011-06-08
WUHAN J H BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Chinese patent ZL.200420096377.3 and application number 200410080305.4 disclose a rapid diagnostic test tube for vacuum blood collection. Although the device can be used for joint inspection of several samples, it can also better solve the problems of iatrogenic infection and environmental pollution, but it has disadvantages Yes: (1) The structure of the device is complicated, the manufacturing cost is high, and the popularization is difficult
(2) The scope of application is limited
The device is only suitable for health technicians to collect blood from the subject for on-site testing, and for some samples that have been collected and prepared in advance, such as blood that has been collected and prepared, serum or plasma that has been separated and prepared, etc. Detection is powerless
(3) The use of vacuum test tubes for blood collection is far from being popularized in the majority of grassroots institutions and rural areas in my country, and vacuum blood collection also sometimes leads to accidents such as iatrogenic infection, pathogen dissemination, and environmental pollution due to failure of blood collection
In addition, Chinese patent application No. 200410099301.0 discloses a colloidal gold test strip that can jointly detect multiple pathogens, and Chinese patent application Nos. 02112230. Although these colloidal gold test strips and colloidal gold percolation devices can achieve various indicators in the joint inspection samples, there are still deficiencies: (1) the joint inspection indicators are all placed on a test paper, and each detection The cross-interference existing between
(2) Serum needs to be separated from the sample to be tested, which is not suitable for the detection of whole blood samples
Moreover, separating serum is not only time-consuming, but also requires certain equipment, reagents and conditions

Method used

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  • Portable fast joint inspection device for foetus teratogenic disease
  • Portable fast joint inspection device for foetus teratogenic disease
  • Portable fast joint inspection device for foetus teratogenic disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Embodiment 1 portable fetal teratogenic disease fast joint detection device structure (combined with figure 1 with figure 2 be explained)

[0049] figure 1 It is a structural side view of the portable rapid joint detection device for fetal teratogenic diseases of the present invention, which includes a suction head 1 and a detection tube 2 connected to the rear end of the suction head 1 . There is a thin tube suction nozzle 12 at the front end of the suction nozzle 1. The suction nozzle 12 is opened with a suction port 13 for sampling. The front end of the suction nozzle 12 can be covered with a rubber protective cap 14. The inner cavity 17 of the suction nozzle is filled from front to back respectively. There are sample filter material 3 and sample water-absorbing material 4, and a test paper fixing column 5 is built in the detection tube 2, and the surface of the column body of the test paper fixing column 5 has four vertical longitudinal strips for fixing HCMV, ...

Embodiment 2

[0062] Example 2 Operation method of the portable rapid joint detection device for fetal teratogenic diseases

[0063] The operating method of the joint inspection device of the present invention is:

[0064] (1) Take out the quick joint inspection device;

[0065] (2) Remove the device head cover 31 of the device and the rubber cap 14 at the front end of the suction head to expose the sample suction port 13, and dip the suction nozzle 12 into the inspection product;

[0066] (3) Within a few minutes, observe whether there is a red line in the corresponding detection line 28 of each built-in test strip detection color development area 25 in the transparent plastic area of ​​the detection tube, and refer to the color development line 29 of the corresponding test strip quality control line to judge whether the sample is provided. Whether the patient suffers from any fetal malformation disease. Test strip detection line 28 and quality control line 29 show a red line, and the de...

Embodiment 3

[0067] Example 3 Application of a portable rapid joint detection device for fetal teratogenic diseases in the rapid joint diagnosis of various early fetal teratogenic diseases

[0068] Use the joint testing device to test different blood samples, and the operation and use method is carried out according to Example 2. The information provided by a maternal and child health hospital in Chengdu shows:

[0069] No. 1 blood sample provider was not infected with any of the above four pathogens, the results are shown in image 3 ;

[0070] Blood sample provider No. 2 was infected with cytomegalovirus, see the results Figure 4 ;

[0071] No. 3 blood sample provider was infected with Toxoplasma gondii, see the results Figure 5 ;

[0072] Blood sample donor No. 4 was infected with cytomegalovirus and herpes simplex virus, see results Image 6 .

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PUM

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Abstract

The invention discloses a portable rapid combined detection device of fetal teratogenic diseases, including a sample suction head (1) and a detection tube (2) which is connected at the back end of the sample suction head (1). The front end of the sample suction head (1) is provided with a thin tube suction mouth (12), the suction mouth (12) is provided with a sample suction port (13) for sample suction, the front end of the suction mouth (12) can be sheathed with a rubber protecting cap (14), an inner cavity (17) of the sample suction head can be respectively filled with sample filter materials (3) and sample water absorbent materials (4) from the front to the back, the interior of the detection tube (2) is provided with a test paper fixed column (5), a cytomegalovirus (HCMV) detection test paper strip, a herpes simplex virus (HSV) detection test paper strip, a rubella virus (RV) detection test paper strip and a toxoplasma (TOX) detection test paper strip are fixedly arranged on the test paper fixed column (5), and the tail end of the detection tube is provided with a sealing cover (7) to seal the waste after detection in the detection tube (2), so as to prevent leakage. All the detection test paper strips (6) which are sealed and fixed in the device are carried out one-time sample suction and the detection with same background, the invention can carry out the combined detection of HCMV antibody, HSV antibody, RV antibody and TOX antibody in the sample at one time within a plurality of minutes by using the naked eye, a plurality of detections of the sample become more simple, safe and rapid; furthermore, the cross-interference can be avoided, the waste after detection is still sealed in the detection tube, so the invention is conductive to the avoidance of spread of pathogens and iatrogenic infection, and is more conductive to the environmentally protective treatment of the waste.

Description

technical field [0001] The invention relates to a medical device and a sample detection test paper, in particular to a portable rapid combined detection device which can be used for diagnosing multiple teratogenic diseases of the fetus at the same time. technical background [0002] Cytomegalovirus (HCMV), herpes simplex virus (HSV), rubella virus (RV), and toxoplasma gondii (TOX) are the most likely causative agents of teratogenic diseases. If a pregnant woman suffers from one of the diseases caused by the above-mentioned pathogens, it may lead to miscarriage, stillbirth, fetal malformation, etc., or long-term sequelae such as mental retardation and audio-visual impairment of the baby. Among them, human cytomegalovirus is the "culprit". It may not have any clinical manifestations after it invades the human body. At present, there are no safe and effective prevention and control measures at home and abroad. Therefore, the inspection of the above-mentioned pathogens has beco...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/569G01N33/558
Inventor 马义才顾敏马灵
Owner WUHAN J H BIO TECH
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