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Microemulsion injection containing injectio natarii norcantharidatis

A technology of sodium norcantharidate and injection, applied in the field of medicine, can solve problems such as adverse reactions

Inactive Publication Date: 2008-07-30
BEIJING HOPE HUGE PHARM SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A microemulsion injection containing sodium norcantharidate of the present invention solves the problem of severe adverse reactions of sodium norcantharidate injections currently available on the market, reduces the pain of patients during the injection process, and has broad application prospects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Embodiment 1: 100 bottles of specifications

[0010] Prescription Norcantharidin Sodium 0.75mg Soybean Oil 7.5ml Co-emulsifier 0.3g Vitamin E 1.2ml Lecithin 1.8ml Glycerin 3.8ml Add water for injection to 150ml

[0011] (1) Disperse lecithin and glycerin in 100ml water to form a water phase;

[0012] (2) sodium norcantharidate, soybean oil, co-emulsifier and vitamin E form the oil phase;

[0013] (3) The two phases are preheated to 70°C respectively;

[0014] (4) Slowly add the oil phase to the water phase and stir at a high speed to obtain colostrum;

[0015] (5) Pass the colostrum through the high-pressure homogenizer, first adjust the two-step valve to 150-180kg / cm 2 , after 3-5 times, then adjust the primary valve to a total pressure of 520-600kg / cm 2 , after 10-15 times, until the capsule meets the requirements;

[0016] (6) Pass the homogenized emulsion over G 4 Vertical melting funnel, filling, flushing with nitrogen, melting and sealing, and sterilizing. ...

Embodiment 2

[0017] Embodiment 2: 1000 bottles of specifications

[0018] Prescription Sodium demethylcantharidinate 7.5mg Soybean oil 75ml Co-emulsifier 3g Vitamin E12ml Lecithin 18ml Glycerin 38ml Add water for injection to 1500ml

[0019] (1) Disperse lecithin and glycerin in 1000ml water to form a water phase;

[0020] (2) sodium norcantharidate, soybean oil, co-emulsifier and vitamin E form the oil phase;

[0021] (3) The two phases are preheated to 70°C respectively;

[0022] (4) Slowly add the oil phase to the water phase and stir at a high speed to obtain colostrum;

[0023] (5) Pass the colostrum through the high-pressure homogenizer, first adjust the two-step valve to 150-180kg / cm 2 , after 3-5 times, then adjust the primary valve to a total pressure of 520-600kg / cm 2 , after 10-15 times, until the capsule meets the requirements;

[0024] (6) Pass the homogenized emulsion over G 4 Vertical melting funnel, filling, flushing with nitrogen, melting and sealing, and sterilizing...

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PUM

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Abstract

The invention discloses a broad-spectrum antineoplastic agent, relating to a micro-emulsified injection with Sodium Demethylcantharidate , which is suitable for the curing of patients with a plurality of tumors such as primary liver cancer, lung cancer, esophagus cancer, nasopharyngeal cancer, malignant lymphoma, bladder cancer, gynecologic malignant tumor and leukopenia, hepatitis, liver cirrhosis and hepatitis b virus, the invention also discloses the preparation method of the medicine, which is characterized in having good curing effect and low adverse reaction.

Description

technical field [0001] The invention relates to a microemulsion injection containing sodium norcantharidate and a preparation method thereof, belonging to the technical field of medicine. technical background [0002] Humans have used mylabris to treat diseases for more than 2,000 years. It is recorded in the silk book "Fifty-two Disease Prescriptions" from the Mawangdui Han Tomb and "Wuwei Han Dynasty Medical Bamboo". Yang Shiying, a famous doctor in the Southern Song Dynasty, clearly recorded in his book "Ren Zhai Zhi Zhi Fang Lun" that mylabris can treat cancer, and it has been 7 centuries so far. The ancients often used the folk prescription of "boiling eggs with mylabris, discarding spots and stinging eggs" to treat liver cancer and other digestive system cancers, and it is still used by the people today. Mylabris is the dried body of Mylabrisphalerata Pall. or M. cichorii L., an insect belonging to the genus Carthariaceae. It tastes pungent, hot, and highly toxic. It ...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/34A61P35/00A61P1/16
Inventor 王翰斌李玉娟
Owner BEIJING HOPE HUGE PHARM SCI
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