Diene oleanolic acid pentacyclic triterpenes derivatives and use thereof

A technology of diene oleanolic acid and pentacyclic triterpenoids, which is applied in the field of polyoxidatively substituted pentacyclic triterpenoid derivatives and its preparation, can solve the high incidence of adverse reactions of non-steroidal anti-inflammatory drugs, liver Functional failure, aggravation of peptic ulcer and other problems
CN101235071AInactive Publication Date: 2008-08-06ZHEJIANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHEJIANG UNIV
Publication Date
2008-08-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a diene oleanolic acid pentacyclic triterpenoid derivative, relative medicine salt or solvate, represented as formula (1). The inventive compound can inhibit the growth activity of tumor cell to be applied in anti-tumor drug and can inhibit mice ear swelling caused by dimethylbenzene to be applied in anti-inflammatory agent. The formula (1) is represented as above.
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Description

[0001] This application is a divisional application of a Chinese patent application with an application date of December 29, 2004 and an application number of 200410102895.6. technical field

[0002] The invention relates to the fields of organic chemistry and medicinal chemistry, in particular, the invention relates to polyoxidatively substituted pentacyclic triterpene derivatives, a preparation method and application thereof. The present invention treats the series of compounds on six tumor cell lines such as human prostate cancer cell (PC-3), nasopharyngeal carcinoma cell line (CNE), oral epithelial cancer cell line (KB), human lung cancer cell (A549), human liver cancer cell line (BEL-7404), human cervical cancer cells (Hela) were screened for tumor cell growth inhibitory activity. The compounds are found to have a certain activity of inhibiting the growth of tumor cells, and can be expected to be used as antitumor drugs. In addition, these compounds also have a significa...

Claims

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