Improved myocardial infarction re-perfusion model, producing and using method thereof

A technique for myocardial infarction and reperfusion, which is applied in the fields of application, medical science, surgery, etc., can solve problems such as high cost and complicated preparation process, and achieve the effects of cost reduction, strong application prospects, and great economic and practical value

Inactive Publication Date: 2008-08-20
TONGJI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In view of the shortcomings of the above two models with complicated preparation process and high cost, the purpose of the present invention is to provide a simpler method to prepare animal models of myocardial infarction reperfusion, which can be used for the experiments of myocardial infarction reperfusion in various small animals. Research, reduce the injury and mortality of experimental animals, and also reduce costs

Method used

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  • Improved myocardial infarction re-perfusion model, producing and using method thereof
  • Improved myocardial infarction re-perfusion model, producing and using method thereof
  • Improved myocardial infarction re-perfusion model, producing and using method thereof

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Embodiment Construction

[0022] Use smooth silk thread and coronary artery parallel ligation method: 3% pentobarbital sodium 30mg / kg body weight ear vein injection anesthesia; no endotracheal intubation and ventilator, keep the rabbit in a natural breathing state; the rabbit is fixed on the operating table supine, cut off Rabbit fur in the chest area was used for skin preparation, disinfected with povidone iodine, and sterile drapes were laid; thoracotomy was made along the median of the sternum to prevent damage to the internal thoracic artery, fully expose the mediastinum and heart, and keep both sides of the pleura intact to prevent pneumothorax; longitudinally Cut the pericardium to fully expose the heart and LAD,

[0023] Step 1, as shown in Figure 1, in which AO is the aorta and PA is the pulmonary artery. Use microsurgical forceps to gently lift the anterior wall of the left ventricle. About 2 mm below the left atrial appendage, that is, 5 mm from the root of the LAD, sew a 7 / 0 non-invasive sut...

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Abstract

The invention relates to an improved reperfusion mode for myocardial infarction of a rabbit and a preparation method, which is characterized in that, putting a silk thread with a diameter not less than the left anterior descending coronary artery (LAD) on the advancing edge of LAD parallelly, ligating the silk thread and LAD together, the ligature divides the silk thread into a long piece and a short piece, the short piece is about 5mm, the long piece is about 160mm in the direction of cardiac apex, checking the silk thread to be not loose, to prepare the mode for myocardial infarction to success; layer-by-layer suture, making the long piece of the silk thread pass through pericardium, sternum and muscle, buried subcutaneously, or putting the outer end of the silk thread on the outside of the skin wound; in the time of reperfusion, opening the skin incision, finding and pulling out the outer end of the silk thread, or directly pulling out the silk thread, to prepare the reperfusion mode for myocardial infarction. The invention can replace the preparation process of the reperfusion mode for myocardial infarction which is completed by two complex operations; the operation is easier, a complex operation combined with a silk thread extraction can complete the preparation of the reperfusion mode for myocardial infarction; the invention decreases the damage of animals, and reduces the cost of the mode preparation.

Description

technical field [0001] The invention belongs to the field of life sciences, in particular to the technical field of reperfusion models of myocardial infarction. Background technique [0002] In the past, the myocardial infarction model was prepared by direct ligation or constriction of the occluded coronary artery, and the preparation of the myocardial infarction reperfusion model required a second operation to cut the ligature or loosen the constriction. Therefore, the trauma to the experimental animals is relatively serious, and secondary anesthesia is required, the model preparation is relatively complicated, and the probability of animal death is increased. At the same time, the cost of the experiment is also high. Contents of the invention [0003] Aiming at the shortcomings of the above two models with complicated preparation process and high cost, the purpose of the present invention is to provide a simpler method to prepare animal models of myocardial infarction re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B19/00A61B90/00
Inventor 赵江民李铭倪炯邵志宏何瑶杨嘉
Owner TONGJI UNIV
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