Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

New therapeutic combinations for the treatment of depression

A composition, technology of antidepressants, in the field of new therapeutic combinations for the treatment of depression, which can solve the problems of hindering patients, compliance, etc.

Inactive Publication Date: 2009-04-15
WYETH LLC
View PDF34 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These side effects often prevent patients from following their recommended treatment regimen

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • New therapeutic combinations for the treatment of depression
  • New therapeutic combinations for the treatment of depression
  • New therapeutic combinations for the treatment of depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0203] Efficacy Evaluation in Tail Suspension Test

[0204] with compound 1 The efficacy of the compounds of the invention in the tail suspension test is illustrated. Although not a direct model of depression, the tail suspension test is an assay that can evaluate the antidepressant-like effects of a drug. Clinically effective drugs such as Prozac (fluoxetine) are effective in this assay. Specifically, they reduced the amount of time mice were immobile after being hung upside down by their tails during the test. It was impossible to determine whether mice were indeed depressed. However, the fact that clinically effective antidepressants reduce immobility lends support to the model's predictive efficacy.

[0205] animal

[0206] Male Swiss Webster mice (Charles River) weighing 20-35 g were used during the study. They were housed 5 per cage with free access to food and water in an AALAC-quality qualified facility maintained on a 12-h light-dark cycle (lights at 0600 h). ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Therapeutic combinations useful in the treatment or prevention of depression or other mood disorders, to pharmaceutical compositions containing said combinations, and to their use in the treatment or prophylaxis of depression or other mood disorders are provided. Such compounds are of formula (I): or a pharmaceutically acceptable salt thereof, wherein each of R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, n and m are as defined and described herein.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Patent Application Serial No. 60 / 785,454, filed March 24, 2006, which is hereby incorporated by reference in its entirety. field of invention [0003] The present invention relates to therapeutic combinations of compounds useful in the treatment or prevention of depression, to pharmaceutical compositions containing such combinations, and to their use in the treatment or prevention of depression. Background of the invention [0004] Worldwide 5-10% of adults suffer from depression. Even more people experience mood disorders associated with depression such as dysthymia, seasonal affective disorder and postpartum depression, bipolar disorder, anxiety disorders, post-traumatic stress disorder, panic disorder and obsessive-compulsive disorder. [0005] The socioeconomic and human costs to individuals and families associated with depression are substantial. People with dep...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4525A61K31/5517A61P25/18A61P25/22A61P25/24
CPCA61K31/5517A61K31/551A61K31/4525A61K31/5513A61K45/06A61P25/00A61P25/18A61P25/22A61P25/24A61P25/28A61P43/00A61K2300/00
Inventor S·罗森茨维希-利普森
Owner WYETH LLC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com