Method for preparing Chinese medicinal composition for preventing and treating menoxenia

A technology for irregular menstruation and composition, which is applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problem that the particle density and size are not easy to be uniform, it is difficult to produce low-excipients for tableting production, and the particle color is dark, etc. problems, to achieve the effect of shortening the heating time of concentration, significant disintegration time, and relatively large fluctuation of weight difference.

Inactive Publication Date: 2009-07-15
NAT ENG RES CENT FOR TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation method disclosed above adopts the wet granulation method, and the Chinese medicine extract needs to be concentrated into a thick extract, which is heated for a long time, and the resulting granules are generally darker in color, and the density and size of the granules are not uniform. Process tablet production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Boil 24g of Motherwort, 12g of Rhizoma Cyperi, 12g of Passepartout, 12g of Rhizoma Chuanxiong, 12g of Wangbuliuxing, and 12g of Caulis Spatholobus with water for 2 extractions. The amount of water added for the first extraction is 10 times the amount of medicine, and the extraction time is 2 hours. The amount of water added for the second time is 7 times the amount of medicine, and the extraction time is 2 hours; filter, combine the filtrate, and concentrate into a water-extracted dilute extract with a relative density of 1.05; put dextrin or starch, etc. in a one-step granulator As a substrate, spray the above water-extracted extract as a binder into a one-step granulator, open the air inlet and outlet, control the negative pressure of -0.02MPa to make the powder boil evenly in the granulator tank, and then heat to control the material The temperature is 30°C, one-step granulation is carried out, and the granulation time is 5 hours; the granules produced by the one-step...

Embodiment 2

[0028]Boil motherwort 5g, Cyperus cyperi 5g, Passepartout 5g, Ligusticum chuanxiong 2g, blancia regia 3g, and Caulis Spatholobus 5g with water for 2 extractions. The amount of water added for the first extraction is 6 times the amount of medicine, and the extraction time is 0.5 hour; the second extraction water addition is 4 times of the dose, and the extraction time is 0.5 hour; filter, merge the filtrate, and concentrate into a water-extracted extract with a relative density of 1.18; put dextrin in a one-step granulator or starch as a substrate, spray the above water-extracted extract as a binder into the one-step granulator, open the air inlet and outlet, control the negative pressure of -0.05MPa to make the powder boil evenly in the granulator tank, and then Heat to control the temperature of the material at 50°C, and carry out one-step granulation, and the granulation time is 3 hours; carry out granulation on the granules made by one-step granulation, add appropriate amoun...

Embodiment 3

[0030] Boil 35g of Motherwort, 20g of Rhizoma Cyperi, 20g of Passepartout, 20g of Rhizoma Chuanxiong, 20g of Wangbuliuxing, and 20g of Miltonia Spatholobus with water, and extract twice. hour; the amount of water added for the second extraction is 10 times the amount of the drug, and the extraction time is 3 hours; add ethanol alcohol precipitation, adjust the alcohol degree to 30%, filter, and concentrate the alcohol precipitation solution to become a water extraction alcohol precipitation solution with a relative density of 1.05 Dilute extract; put dextrin or starch in the one-step granulator as a substrate, spray the above-mentioned water-extracted alcohol-sinking dilute extract as a binder into the one-step granulator, open the air inlet and outlet, and control it at -0.03MPa The negative pressure makes the powder boil evenly in the tank of the granulator, and then heats the material to control the temperature at 40°C for one-step granulation. The granulation time is 4 hour...

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Abstract

The invention discloses a preparation method of a traditional Chinese medicine composition for preventing and treating irregular menstruation. The method comprises the following steps: concentrating a certain quantity of raw materials medicine including motherwort, cyperus tuber, sweetgum fruit, hemlock parsley, seed of cowherb and spatholobus stem into water extract diluted extractum by water extraction, or concentrating the raw material medicine into water extraction and alcohol precipitation diluted extractum by water extraction and alcohol precipitation, then putting dextrin, starch or the like used as substrates into a one-step granulating machine, spraying the water extract diluted extractum or the water extraction and alcohol precipitation diluted extractum used as a binding agent into the one-step granulating machine for one-step granulation, finally grinding grains, and adding other auxiliary materials to prepare traditional Chinese medicine preparation for oral administration. The method can significantly reduce the quantity of the auxiliary materials, shorten the processing time and the heating time for condensation and drying, avoid the damage to the effective ingredients of the traditional Chinese medicine composition, simplify the process flow and reduce the energy consumption. The flowability of the prepared granules is high, the disintegration of compressed tablets is fast, the production process is not easily polluted, and the quality of finished products is ensured well.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine composition, in particular to a preparation method of a traditional Chinese medicine composition for preventing and treating irregular menstruation. Background technique [0002] Gynecological diseases—Irregular menstruation refers to gynecological diseases characterized by abnormal menstrual cycle, menstrual period, menstrual volume, menstrual color, and menstrual quality, or symptoms accompanied by menstrual cycle, including early menstruation, late menstruation, irregular menstruation, menorrhagia, Dysmenorrhea, etc., as well as systemic symptoms such as headache, insomnia, and diarrhea caused by irregular menstruation. [0003] According to the survey and statistics of the Ministry of Health, the incidence rate of gynecological diseases in my country is as high as 75%, among which patients with irregular menstruation and dysmenorrhea account for about 50%. According to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8905A61K9/16A61P15/00
Inventor 虞伟阮克锋路钧镧
Owner NAT ENG RES CENT FOR TRADITIONAL CHINESE MEDICINE
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