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Preparation method of traditional Chinese medicine composition for preventing and treating irregular menstruation

A technology of irregular menstruation and composition, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc. It can solve the problem of difficulty in uniform particle density and size, difficulty in making tablets with low auxiliary materials, long heating time, etc. problems, to achieve the effect of shortening the concentrated heating time, significant disintegration time, and improved particle size uniformity

Inactive Publication Date: 2011-04-13
NAT ENG RES CENT FOR TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation method disclosed above adopts the wet granulation method, and the Chinese medicine extract needs to be concentrated into a thick extract, which is heated for a long time, and the resulting granules are generally darker in color, and the density and size of the granules are not uniform. Process tablet production

Method used

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  • Preparation method of traditional Chinese medicine composition for preventing and treating irregular menstruation
  • Preparation method of traditional Chinese medicine composition for preventing and treating irregular menstruation

Examples

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Embodiment 1

[0026] Boil 24g of Motherwort, 12g of Rhizoma Cyperi, 12g of Passepartout, 12g of Rhizoma Chuanxiong, 12g of Wangbuliuxing, and 12g of Caulis Spatholobus with water for 2 extractions. The amount of water added for the first extraction is 10 times the amount of medicine, and the extraction time is 2 hours. The amount of water added for the second time is 7 times the amount of medicine, and the extraction time is 2 hours; filter, combine the filtrate, and concentrate into a water-extracted dilute extract with a relative density of 1.05; put dextrin or starch, etc. in a one-step granulator As a substrate, spray the above water-extracted extract as a binder into a one-step granulator, open the air inlet and outlet, control the negative pressure of -0.02MPa to make the powder boil evenly in the granulator tank, and then heat to control the material The temperature is 30°C, one-step granulation is carried out, and the granulation time is 5 hours; the granules produced by the one-step...

Embodiment 2

[0028]Boil motherwort 5g, Cyperus cyperi 5g, Passepartout 5g, Ligusticum chuanxiong 2g, blancia regia 3g, and Caulis Spatholobus 5g with water for 2 extractions. The amount of water added for the first extraction is 6 times the amount of medicine, and the extraction time is 0.5 hour; the second extraction water addition is 4 times of the dose, and the extraction time is 0.5 hour; filter, merge the filtrate, and concentrate into a water-extracted extract with a relative density of 1.18; put dextrin in a one-step granulator or starch as a substrate, spray the above water-extracted extract as a binder into the one-step granulator, open the air inlet and outlet, control the negative pressure of -0.05MPa to make the powder boil evenly in the granulator tank, and then Heat to control the temperature of the material at 50°C, and carry out one-step granulation, and the granulation time is 3 hours; carry out granulation on the granules made by one-step granulation, add appropriate amoun...

Embodiment 3

[0030] Boil 35g of Motherwort, 20g of Rhizoma Cyperi, 20g of Passepartout, 20g of Rhizoma Chuanxiong, 20g of Wangbuliuxing, and 20g of Miltonia Spatholobus with water, and extract twice. hour; the amount of water added for the second extraction is 10 times the amount of the drug, and the extraction time is 3 hours; add ethanol alcohol precipitation, adjust the alcohol degree to 30%, filter, and concentrate the alcohol precipitation solution to become a water extraction alcohol precipitation solution with a relative density of 1.05 Dilute extract; put dextrin or starch in the one-step granulator as a substrate, spray the above-mentioned water-extracted alcohol-sinking dilute extract as a binder into the one-step granulator, open the air inlet and outlet, and control it at -0.03MPa The negative pressure makes the powder boil evenly in the tank of the granulator, and then heats the material to control the temperature at 40°C for one-step granulation. The granulation time is 4 hour...

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Abstract

The present invention discloses a preparation method of traditional Chinese medicine composition for preventing and treating irregular menstruation, wherein the method comprises the following steps of: concentrating a certain amount of crude drugs containing certain ingredients (leonurus, Ligusticum wallichii, semen vaccariae and leatherleaf milletia) into a water extracted dilute extract via water extraction, or alcohol precipitating and concentrating the crude drugs into a water extracted and alcohol precipitated dilute extract via water extraction; then placing dextrin or starch and the like as a substrate into a one-step granulator, spraying the water extracted dilute extract or the water extracted and alcohol precipitated dilute extract acting as an adhesion agent into the one-step granulator for one-step granulation; finally, performing granule shaping, adding other accessories to prepare traditional Chinese medicine oral preparation. The method can reduce accessory amount obviously, shorten processing time and heated time for concentrating and drying, and prevent the effective constituents in the traditional Chinese composition from destroying; the prepared granule has good liquidity; the disintegration of the pressed tablet is faster; the process flow is simplified and energy consumption is reduced; the composition is seldom polluted during the production; the quality of finished product is ensured better.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine composition, in particular to a preparation method of a traditional Chinese medicine composition for preventing and treating irregular menstruation. Background technique [0002] Gynecological diseases—Irregular menstruation refers to gynecological diseases characterized by abnormal menstrual cycle, menstrual period, menstrual volume, menstrual color, and menstrual quality, or symptoms accompanied by menstrual cycle, including early menstruation, late menstruation, irregular menstruation, menorrhagia, Dysmenorrhea, etc., as well as systemic symptoms such as headache, insomnia, and diarrhea caused by irregular menstruation. [0003] According to the survey and statistics of the Ministry of Health, the incidence rate of gynecological diseases in my country is as high as 75%, among which patients with irregular menstruation and dysmenorrhea account for about 50%. According to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/533A61P15/00
Inventor 虞伟阮克锋路钧镧
Owner NAT ENG RES CENT FOR TRADITIONAL CHINESE MEDICINE
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