The invention belongs to the field of medicinal preparations, and discloses an indissolvable
drug oral sustained-release dry
emulsion tablet and a preparation method thereof. The preparation method for the oral sustained-release dry
emulsion tablet comprises the steps that after an
oil phase, a surface
active agent and cosurfactant are evenly mixed, an indissolvable
drug is added till the
drug is dissolved completely, and accordingly a
medicine-carried self-emulsifying
system is prepared; after the
medicine-carried self-emulsifying
system and an
aqueous solution of a hydrophilic gel framework material are evenly mixed,
spray drying is conducted, and sustained-release dry
emulsion powder is obtained; after the sustained-release dry emulsion
powder and a conventional tablet auxiliary material needed for preparation are mixed, wet
granulation is carried out; at last, tabletting is performed. The sustained-release dry emulsion tablet can improve the
dissolution and dissolving-out performance of the indissolvable drug, the
bioavailability of the indissolvable drug is improved, a stable
blood concentration is formed, and the compliance of patients is improved. The sustained-release dry emulsion tablet is not complex in composition of prescription, and the preparation technology is suitable for industrial production.