The invention discloses an industrialized preparation method of guacetisal, which comprises the following steps: based on salicylic acid and guaiacol as raw materials, carrying out esterification on the raw materials so as to obtain salicylic acid-guaiacol ester; and then, carrying out acetylization on hydroxy so as to obtain guacetisal, wherein in the esterification reaction, one of pyridine, 4-dimethylamino-pyridine and dimethylformamide is selected as a catalyst; and in the step of carrying out acetylization on hydroxy, one of pyridine, 4-dimethylamino-pyridine and dimethylformamide is added and used as an auxiliary alkali reagent. According to the invention, the technological production cost is low, the synthetic route is short, the reaction rate is improved, and the reaction temperature is reduced, so that the reaction temperature is milder and the preparation method is suitable for industrialized production; the post-treatment processes of esterification and acetylization reactions are simple, complicated quenching, extraction and solvent replacement operations are avoided, the time of batch production is greatly reduced, and the application amount of organic solvents is maximally reduced; and therefore, the industrialized preparation method of guacetisal is particularly suitable for industrialized production.