The invention relates to a bone repair material for large-volume defect of mandible, and belongs to the technical field of bone repair. The bone repair material is an organic/inorganic composite material, an organic phase comprises collagen, silk fibroin and toughened polylactic acid, an inorganic phase comprises nano-hydroxyapatite and zinc silicate, and the bone repair material is prepared through the following steps that 1, collagen/silk fibroin-based nano-hydroxyapatite is prepared; step 2, preparation of toughened polylactic acid; and 3, mixing the mixed powder, the zinc silicate powder and the toughened polylactic acid solution, uniformly stirring, freezing at-20 to-10 DEG C for 24-48 hours, freezing at 0 DEG C for 24-48 hours, carrying out vacuum drying, crushing, screening, adding into a mold, and carrying out cold press molding, so as to obtain the bone repair material for the large-volume defect of the lower jawbone. The bone repair material provided by the invention has excellent strength and toughness, and excellent biocompatibility and degradation rate.