The invention discloses a low-noise pre-amplifier. The low-noise pre-amplifier comprises a power supply, a first resistor, a second resistor, a third resistor, a fourth resistor, a fifth resistor, a sixth resistor, a seventh resistor, an eighth resistor, a ninth resistor, a tenth resistor, an eleventh resistor, a first capacitor, a second capacitor, a third capacitor, a fourth capacitor, a fifth capacitor, a sixth capacitor, a seventh capacitor, an eighth capacitor, a ninth capacitor, a first N-channel field-effect transistor, a second N-channel field-effect transistor, an integrated operational amplifier, a low-pass filter composed of the eleventh resistor, the eighth capacitor, the ninth capacitor and the tenth resistor and a differential amplifier composed of the first N-channel field-effect transistor and the second N-channel field-effect transistor. The low-noise pre-amplifier is provided with the low-pass filter composed of the eleventh resistor, the eighth capacitor, the ninth capacitor and the tenth resistor, so high-frequency signals among acoustical signals can be filtered out; moreover, the high-quality low-noise N-channel field-effect transistors are selected for the pre-amplifier, so that the anti-interference performance of the pre-amplifier is improved.