Indissolvable drug oral sustained-release dry emulsion tablet and preparation method thereof
A technology of insoluble drugs and dry milk tablets, which is applied in the fields of pharmaceutical formula, drug combination, drug delivery, etc., can solve the problems of short half-life, short duration of drug effect, prolonged duration of drug effect, peak and valley phenomenon of blood drug concentration, etc. Achieve the effects of reducing the first-pass effect of the liver, taking less times, and improving oral bioavailability
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Embodiment 1
[0042] Prescription composition:
[0043]
[0044] 3% PVPK30 in 70% ethanol solution as adhesive, made 1000 pieces in total
[0045] Preparation Process:
[0046] 1) The drug is completely dissolved in the self-emulsifying system to obtain the drug-loaded self-emulsifying system;
[0047] 2) adding a small amount of water to the drug-loaded self-emulsifying system to make it self-emulsified, and then mixing it with an aqueous solution of HPMCK4M for spray drying to obtain a material liquid for spray drying;
[0048] 3) spray drying;
[0049] 4) Sieve and mix dry milk powder with extra HPMC and lactose, use 3% PVPK30 in 70% ethanol solution as binder, sieve and granulate at 20 mesh, dry at 45°C for 4 hours, granulate at 20 mesh, and finally add lubricant Tablet.
[0050] The obtained felodipine oral sustained-release dry milk tablet was tested for release according to the following dissolution method. Its drug release curve is shown in figure 1 .
[0051] According to...
Embodiment 2
[0053] Prescription composition:
[0054]
[0055]
[0056] A 70% ethanol solution of 3% PVPK30 was used as an adhesive to make a total of 1000 dosage units. The preparation process was the same as in Example 1.
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