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Preparing method for compressible saccharose

A technology of compressibility and sucrose, which is applied in the field of preparation of compressible sucrose, can solve the problems of complex process and low yield, and achieve the effect of good fluidity

Active Publication Date: 2016-08-10
HUNAN ER KANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method has the disadvantages of complicated process and low yield.

Method used

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  • Preparing method for compressible saccharose

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Crush and sieve sucrose to obtain 100-mesh sucrose powder; sieve talcum powder to obtain 100-mesh sucrose powder; weigh 20kg sucrose powder and 0.04kg talcum powder; weigh 1kg maltodextrin, add 6kg water, stir evenly to dissolve ; Turn on the fluidized bed system, feed gas into the fluidized bed from the air inlet, and heat the system to the predetermined temperature: the upper temperature control point is set at 200°C, and the lower temperature control point is set at 75°C; The sucrose powder is added into the fluidized bed at one time and the bed is sealed; adjust the air flow of the air inlet to 0.3Mpa to fluidize the sucrose; after the system temperature is stabilized at the set value, start the spray device to spray into particles The air pressure of the nozzle is 0.5MPa; after spraying a certain amount of solution, continue to heat and maintain fluidization for several 10 minutes, so that the solute sprayed into the droplets in the later stage is completely decompo...

Embodiment 2

[0030] Crush and sieve sucrose to obtain 80-mesh sucrose powder; sieve talc powder to obtain 80-mesh talc powder; weigh 20kg sucrose powder and 0.06kg talcum powder; weigh 0.6kg sorbitol, add 3kg water, stir evenly to dissolve ; Turn on the fluidized bed system, feed gas into the fluidized bed from the air inlet, and heat the system to the predetermined temperature: the upper temperature control point is set at 180°C, and the lower temperature control point is set at 65°C; The sucrose powder and talcum powder are added into the fluidized bed at one time and the bed is sealed; the air flow at the air inlet is adjusted to 0.25Mpa to fluidize the sucrose; after the system temperature is stabilized at the set value, the spray device is started to carry out Spray into particles; the air pressure of the nozzle is 0.3MPa; after spraying a certain amount of solution, continue to heat and maintain fluidization for 8 minutes, so that the solute sprayed into the droplets in the later stag...

Embodiment 3

[0032] Crush and sieve the sucrose to obtain 100-mesh sucrose powder; sieve talc powder to obtain 100-mesh sucrose powder; weigh 20 kg of sucrose powder and 0.04 kg of talc powder; weigh 0.5 kg of starch, add 6 kg of water, stir evenly, and dissolve it; Turn on the fluidized bed system, feed gas into the fluidized bed from the air inlet, and heat the system to the predetermined temperature: the upper temperature control point is set at 200°C, and the lower temperature control point is set at 75°C; the weighed Add sucrose powder to the fluidized bed at one time and seal the bed; adjust the air flow at the air inlet to 0.3Mpa to fluidize the sucrose; after the system temperature is stabilized at the set value, start the spray device to spray into particles; The air pressure of the nozzle is 0.5MPa; after spraying a certain amount of solution, continue to heat and maintain fluidization for 10 minutes, so that the solute sprayed into the droplets in the later stage is completely de...

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Abstract

The invention relates to a preparing method for compressible saccharose .The method comprises the steps that saccharose serves as a main raw material, a crystallizing resisting agent and talcum powder serve as auxiliary materials, a fluidized bed is used for spraying drying, and compressible saccharose particles are obtained .The method is simple in technological process and small in investment and energy consumption; besides, the obtained compressible saccharose is good in compressibility and mobility, high in uniformity and free of agglomeration .

Description

technical field [0001] The invention relates to a preparation method of compressible sucrose. Background technique [0002] Compressible sucrose is a new variety derived from deep processing of sucrose. It is a physical and chemical modification of sucrose so that it no longer has the original crystal form and becomes an amorphous powder. Compressible sucrose can overcome some defects of sucrose in tablet making, such as poor fluidity and high hardness, which can easily cause tablet splits and uneven tablet weight, etc., while completely retaining the inherent sweetness and sensory properties of sucrose, so it can be compressed Sucrose is a good tableting material. Compared with sucrose, compressible sucrose is more convenient to use as an excipient for tablets. It can be directly used for tablet compression without going through the process of making soft materials and granulating, reducing the intermediate links in tablet production. Excellent excipient and excipient for...

Claims

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Application Information

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IPC IPC(8): A61K47/26A61K47/36A61K47/02A61K9/16A23L27/30A23L29/30A23L33/12
CPCA61K9/1623A61K47/02A61K47/26A61K47/36
Inventor 帅放文王向峰章家伟
Owner HUNAN ER KANG PHARMA
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