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Chinese medicinal composition for treating breast cancer and preparation method thereof

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition and its preparation for the treatment of breast cancer, can solve the problems of high incidence and slow progress of the disease

Inactive Publication Date: 2009-07-22
BEIJING TIANKE RENXIANG MEDICAL SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Has a high incidence and is quite aggressive, but the course of the disease progresses slowly

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1 Chinese medicine composition granule of the present invention

[0026] 1. Prescription

[0027] 9 parts Cyperus 9 parts Zhe Fritillaria Angelica 9 parts

[0028] 9 parts of Radix Paeoniae Rubra, 9 parts of Tangerine Peel, 9 parts of Wang Buliuxing

[0029] 9 parts of Shanjia Zhu, 12 parts of whole melon wilt, 12 parts of Polygonum cuspidatum

[0030] Silver flower 12 parts Forsythia 12 parts Hedyotis diffusa 18 parts

[0031] 2. Preparation process

[0032] (1) Cyperus Cyperi, Fritillaria, Angelica, Radix Paeoniae Rubra, Tangerine Peel, Wangbuliuxing, Shanjiazhu, Quanguawei, Polygonum cuspidatum, Silver Flower, Forsythia, Hedyotis diffusa, decoct twice with water, the first 2 hours for the second time, 1 hour for the second time, filter, combine and concentrate the filtrates to obtain a clear paste (d=1.15-1.25, 60°C);

[0033] (2) Dry and pulverize the clear paste, add 600 g of lactose and 200 g of dextrin, and wet granulate with 70% ethanol to get fi...

Embodiment 2

[0034] Embodiment 2 Chinese medicine composition capsule of the present invention

[0035] 1. Prescription

[0036] 9 parts Cyperus 9 parts Zhe Fritillaria Angelica 9 parts

[0037] 9 parts of Radix Paeoniae Rubra, 9 parts of Tangerine Peel, 9 parts of Wang Buliuxing

[0038] 9 parts of Shanjia Zhu, 12 parts of whole melon wilt, 12 parts of Polygonum cuspidatum

[0039] Silver flower 12 parts Forsythia 12 parts Hedyotis diffusa 18 parts

[0040] 2. Preparation process

[0041] (1) Cyperus Cyperi, Fritillaria, Angelica, Radix Paeoniae Rubra, Tangerine Peel, Wangbuliuxing, Shanjiazhu, Quanguawei, Polygonum cuspidatum, Silver Flower, Forsythia, Hedyotis diffusa, decoct twice with water, the first 2 hours for the second time, 1 hour for the second time, filter, combine and concentrate the filtrates to obtain a clear paste (d=1.15-1.25, 60°C);

[0042] (2) Dry and pulverize the clear paste, add 200g of starch, mix well, and put it into an empty capsule.

[0043] Animal experi...

experiment example

[0045] 1. Materials and methods

[0046] 1.1 Experimental animals: 48 615-series mice, all female, weighing about 20g, aged 6 weeks;

[0047] 1.2 Drugs and reagents: Cyclophosphamide (CTX) 200mg / bottle, diluted to 4mg / ml with normal saline; immunohistochemical reagent nm23 (working concentration 1:100) and Cath-D monoclonal antibody (working concentration 1:200 );

[0048] 1.3 Tumor strain and model establishment: 2×106 Ca761 cells were transplanted subcutaneously in the right axilla of 615-line mice to establish a mouse breast cancer transplantation model. Start the medication the day after vaccination.

[0049] 1.4 Grouping of experimental animals: After modeling, they were randomly divided into 4 groups with 12 animals in each group.

[0050] (1) Blank control group (NS group); normal saline (NS) 0.2ml gavage d×21d

[0051] (2) Western medicine control group (CTX group): CTX 40mg / kg·intraperitoneal injection·d×21d

[0052] (3) Chinese medicine treatment group (Z group)...

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PUM

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Abstract

The invention relates to a traditional Chinese medicine composition for treating breast cancer. The traditional Chinese medicine composition is prepared from nutgrass galingale rhizome, fritillary bulb, angelica, red paeony root, dried orange peel, seed cowherb, Chinese pangolin, full fructus trichosanthis, giant knotweed, honeysuckle flower, forsythia, oldenlandia diffusa and / or pharmaceutically acceptable carrier. The invention also relates to a method for preparing the traditional Chinese medicine composition. The traditional Chinese medicine composition has the efficacies of soothing liver and strengthening spleen, reducing stagnation, invigorating blood circulation and softening hardness to dissipate stagnation, and is suitable for patients suffering from interrelation between phlegm and blood stasis, mammary gland lump, swelling pain and mammary gland lobular hyperplasia.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a traditional Chinese medicine composition for treating breast cancer and a preparation method thereof. Background technique [0002] Breast cancer (mammary carcinoma) is the most common malignant tumor in humans, and it is also one of the main malignant tumors in women. It mainly occurs in women, rare in men, and the incidence rate of women is nearly 100 times that of men. The incidence of breast cancer varies greatly from country to country due to differences in geographical environment and living habits. Most countries in North America and Northern Europe have a high incidence of female breast cancer, some countries in South America and Southern Europe have a moderate incidence, and most of Asia, Latin America, and Africa have a low incidence. In North America, Europe and other developed countries, the incidence of female breast ...

Claims

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Application Information

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IPC IPC(8): A61K36/8966A61K9/16A61K9/48A61P15/14A61P35/00A61K35/36
Inventor 王丽娟
Owner BEIJING TIANKE RENXIANG MEDICAL SCI TECH
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