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Influenza-pandemic influenza bivalent combined vaccine and preparation method thereof

A combined vaccine and influenza vaccine technology, applied in the fields of influenza-pandemic influenza combined vaccine and its preparation, combined vaccine and its preparation, can solve problems such as no reports, reduce vaccine cost and market price, and reduce the number of vaccinations , significant economic benefits

Inactive Publication Date: 2009-09-09
CHENGDU KANGHUA BIOLOGICAL PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In addition, there has not been any report on the combination vaccine of influenza and avian influenza, which are both infected by influenza virus.

Method used

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  • Influenza-pandemic influenza bivalent combined vaccine and preparation method thereof
  • Influenza-pandemic influenza bivalent combined vaccine and preparation method thereof
  • Influenza-pandemic influenza bivalent combined vaccine and preparation method thereof

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Experimental program
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Effect test

Embodiment Construction

[0031] Its preparation process of oral influenza-pandemic influenza combined vaccine involved in the present invention is as follows:

[0032] (1) Preparation of influenza and avian influenza vaccine seed banks: Like other influenza vaccines of various dosage forms, a three-level seed bank of primary generation, main generation, and working generation should be established. The three-level seed bank must be verified: hemagglutination titer , virus titer, sterility test, mycoplasma, identification test, exogenous factors (poultry adenovirus, leukemia virus detection) and other items.

[0033] (2) Preparation of influenza and avian influenza virus liquid: working seeds are inoculated with chicken embryos, cultured, harvested virus liquid, clarified, filtered, purified and inactivated to make whole virus liquid, subject to verification: hemagglutination content, sterility Test, inactivation test, identification test and other items. After that, it is prepared according to the pr...

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Abstract

The invention provides a high-efficiency low-cost influenza-pandemic influenza bivalent combined vaccine which can be produced in large amount and a preparation method thereof, relating to a novel influenza-pandemic influenza vaccine preparation used for injection and a preparation process thereof and comprising preparation of virus seed banks and production and preparation of vaccine stock solution. The preparation method refers to that of whole-virus inactivated vaccines, split vaccines and subunit vaccines of the influenza and split vaccines of the pandemic influenza. The influenza-pandemic influenza bivalent combined vaccine preparation provided by the invention comprises two antigens for influenza and bird flu and can conveniently prevent viral epidemics and outbreak of the influenza and bird flu.

Description

technical field [0001] The invention relates to the field of bioengineering, in particular to a combined vaccine and a preparation method thereof, in particular to an influenza-pandemic influenza combined vaccine and a preparation method thereof. Background technique [0002] Influenza is called influenza for short, and is an acute respiratory infectious disease caused by three types of influenza virus (influenza virus) of A, B, and C respectively. The prevalence of influenza A usually causes a worldwide influenza pandemic and can cause influenza epidemics in livestock and poultry; Type B often causes local outbreaks of influenza, but does not cause a worldwide influenza pandemic; Type C appears in the form of sporadic cases , mainly attack infants and young children, and generally do not cause influenza epidemics. The epidemiological characteristics of influenza are sudden outbreak, rapid spread, wide spread, high morbidity rate, and high mortality rate in the elderly, fra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/295A61K39/145A61P31/16
Inventor 李声友朱文漓
Owner CHENGDU KANGHUA BIOLOGICAL PROD
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