Children acute lymphoblastic leukaemia genotyping diagnosis chip

Abstract

The invention discloses a children acute lymphoblastic leukaemia genotyping diagnosis chip. The children acute lymphoblastic leukaemia genotyping diagnosis chip is a DNA chip which is fixed with 62 DNA fragment arrays on the surface of a carrier. .The nucleotide sequences of the 62 DNA fragment arrays are respectively the sequence 1 to the sequence 62 of the sequence list. The invention further discloses a children acute lymphoblastic leukaemia genotyping method. The genetic chip of the invention can provide precise typing so as to help correctly choose a chemo-treatment plan of appropriate strength, thereby reducing complicating disease and improving curative ratio and life quality. The genetic chip of the invention can be used to carry out genotyping on childhood ALL. Therefore, the genetic chip not only saves diagnosis cost, but also has significance in protecting labour resource and promoting family and society harmony.

Description

technical field [0001] The invention relates to a chip for genotype diagnosis of children's acute lymphocytic leukemia. Background technique [0002] Childhood leukemia is the most common malignant tumor in childhood, accounting for 30% of childhood tumors. There are about 20,000 new cases of childhood leukemia in my country every year, among which acute lymphoblastic leukemia (ALL) is the most common type, accounting for 75% to 80% of childhood leukemia. After the 1980s, due to multi-drug combination intensive chemotherapy and strong supportive treatment, the cure rate of children ALL has reached more than 80% in developed countries in the world, and more than 75% in advanced hospitals such as Beijing and Shanghai. However, in the past 30 years The cure rate of ALL has not been significantly improved, and clinical studies have confirmed that more intensive chemotherapy may not improve the cure rate, but will increase chemotherapy-related mortality and secondary tumors. Th...

AI Technical Summary

Problems solved by technology

After the 1980s, due to multi-drug combination intensive chemotherapy and strong supportive treatment, the cure rate of children ALL has reached more than 80% in developed countries in the world, and more than 75% in advanced hospitals such as Beijing and Shanghai. However, in the past 30 years The cure rate of ALL has not been significantly improved, and clinical studies have confirmed that more intense chemotherapy may not improve the cure rate, but will increase chemotherapy-related mortality and secondary tumors

[0016] Although whole-genome microarrays have been proven to be effective in the genetic diagnosis and typing of leukemia, the high price and complicated analysis methods make it face great difficulties in clinical application

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