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Method for preparing Chinese medicinal preparation for treating external respiration infection of children

A technology for traditional Chinese medicine preparations and respiratory tract, applied in the field of preparation of traditional Chinese medicine preparations, can solve the problems of rough preparation process, difficult to guarantee curative effect and the like

Active Publication Date: 2011-08-17
BEIJING ASIA EAST BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The preparation process is relatively rough, and there are some unreasonable points, and the curative effect is difficult to guarantee. Therefore, it is necessary to conduct further research on the preparation process to make it more specific and scientific. This is also one of the directions of modernization of traditional Chinese medicine.

Method used

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  • Method for preparing Chinese medicinal preparation for treating external respiration infection of children
  • Method for preparing Chinese medicinal preparation for treating external respiration infection of children
  • Method for preparing Chinese medicinal preparation for treating external respiration infection of children

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0019] Experimental example 1 Determination of the amount of water added for decocting ephedra

[0020] Take 3 portions of ephedra, 90g each, decoct for 2 hours for the first time, and 1 hour for the second time, divide into 3 groups for testing, add 6 times and 4 times the amount of water in the first group, add 8 times the amount of water in the second group Double the amount, 6 times the amount, the third group added 10 times the amount of water, 8 times the amount, combined the decoction, filtered, left standstill, and got the supernatant to measure the content of ephedrine hydrochloride.

[0021] According to high-performance liquid chromatography, octadecylsilane bonded silica gel is used as filler, acetonitrile-0.1% phosphoric acid solution (containing 0.1% triethylamine) (3:97) is used as mobile phase, and the detection wavelength is 205nm. The number of theoretical plates should not be less than 4000 based on the calculation of ephedrine hydrochloride. Take an approp...

experiment example 2

[0026] Experimental example 2 Determination of the amount of water added for decocting Scutellaria baicalensis

[0027] Take 3 parts of Scutellaria baicalensis, 180g each, decoct for 2 hours for the first time, and 1 hour for the second time, divide into 3 groups for testing, add 6 times and 4 times the amount of water in the first group, add 8 times the amount of water in the second group Double the amount, 6 times the amount, add 10 times the amount of water to the third group, 8 times the amount, combine the decoction, filter, let stand, take the supernatant to determine the content of baicalin, the results are shown in Table 2:

[0028] Table 2: Determination of the amount of water added for decocting ephedra

[0029]

[0030] Taking the content of baicalin as an indicator, it can be seen that the second group (8 times the amount of water added, 6 times the amount) and the third group (the amount of water added 10 times, 8 times the amount), the ointment rate is not muc...

experiment example 3

[0031] Experimental example 3 Effect of co-decoction and separate decoction of ephedra and scutellaria baicalensis on the dissolved components

[0032] Take 90g of ephedra and 180g of Scutellaria baicalensis and decoct together. For the first time, add 8 times the amount of water to decoct for 2 hours, and for the second time, add 6 times the amount of water to decoct for 1 hour. Combine the decoction, filter, stand still, and take the supernatant to determine The contents of ephedrine hydrochloride and baicalin, combined with the results of experimental examples 1 and 2, analyzed the effects of co-decoction and separate decoction of ephedra and scutellaria baicalensis on the dissolution components, see Table 3:

[0033] Table 3: Effects of co-decoction and separate decoction of ephedra and scutellaria baicalensis on the dissolved components

[0034]

[0035]

[0036] From the above experimental results, it can be seen that the active ingredients ephedrine hydrochloride ...

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Abstract

The invention relates to a method for preparing a Chinese medicinal preparation for treating external respiration infection of children. In the method, the pharmic and pharmacological tests are combined to systematically control parameters of the preparation process, and by the tests, we found that the separate decoction of Chinese ephedra and baikal skullcap root better facilitates the extraction of active components. The preparation prepared by the method has the characteristics of high efficiency and stability in pharmacological effect.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine preparation for treating children with external respiratory tract infection, belonging to the technical field of traditional Chinese medicine. Background technique [0002] Xiaoer Qingre Zhike Oral Liquid comes from page 348 of "Pharmacopoeia of the People's Republic of China" (1st Edition, 2005), and its prescription and preparation method are as follows: [0003] [Prescription] Ephedra 90g Bitter almond (fried) 120g Gypsum 270g Licorice 90g [0004] Scutellaria baicalensis 180g Banlangen 180g Northern bean root 90g [0005] [Preparation method] The above seven flavors, ephedra, gypsum, add water and decoct for half an hour, then add five flavors such as bitter almond, decoct twice, the first time for 2 hours, the second time for 1 hour, combine the decoction, filter, and decompress the filtrate Concentrate to about 600ml, let stand for 24 hours, filter, add honey 200g, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/736A61P11/00A61K33/06
Inventor 付立家付建家
Owner BEIJING ASIA EAST BIO PHARMA CO LTD