Application of lignin flavanonol in preparation of antiviral drugs

Abstract

The invention relates to application of lignin flavanonol in preparation of antiviral drugs, particularly, the invention relates to a chemical compound as formula (I), (+-)-2-[2,3-dihydro-2-(3,5-dimethoxy-4-hydroxy phenyl)-3-hydroxymethyl-1,4-benzodioxane-5]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyrone-4-ketone, or use of its medicinal salt used for preparing drugs for repressing virus infectioncaused by herpes simplex virus HSV-1 and / or drugs for curing oral ulcer. The chemical compound is prepared by chemical synthesis, pharmacological experiments shows that, the chemical compound has powerful inhibitory action to the herpes simplex virus HSV-1, and the half inhibitory concentration value IC[50] is 39.41 mg / mL.

Description

Application of lignin dihydroflavonol in the preparation of drugs for inhibiting herpes simplex virus technical field The present invention relates to the technical field of medicine, in particular, the present invention relates to a lignin dihydroflavonol derivative, namely the compound (±)-2-[2,3-dihydro-2-(4-hydroxyphenyl)-3 -Hydroxymethyl-1,4-benzodioxane-5]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one or its druggable Use of salt for preparing medicine for inhibiting virus infection caused by herpes simplex virus HSV-1 and / or treating oral ulcer. Background technique Herpes simplex virus can be divided into two types: type I and type II. Type I herpes virus (HSV-1) mainly infects the skin, mucous membranes and organs above the waist. HSV-1 is mainly transmitted through close contact with the respiratory tract, skin and mucous membranes. 99% Inflammation and herpes of the oral mucosa, nasal vestibule, conjunctiva, throat, and herpes around the mouth are all caus...

AI Technical Summary

Problems solved by technology

The silybin compounds have the above-mentioned definite multiple curative effects, but their new application in antiviral aspects, especially the inhibition of herpes simplex virus, has not been effectively developed, so the present invention selects and prepares the The different new derivatives, that is, the introduction of dioxane substituents with different parallel positions in the flavone B ring, thus forming a new class of lignin dihydroflavonol compounds, and tested their inhibition of type I simple Pharmacological activity of herpes virus HSV-1, in order to obtain new drugs or lead compounds that inhibit HSV-1 virus independent intellectual property rights

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