Application of lignin flavanonol in preparation of antiviral drugs
A technology for dihydrogen and drugs, applied in the field of medical technology, can solve problems such as not being effectively developed, and achieve the effects of convenient source of raw materials, high yield, and easy-to-obtain raw material sources.
A technology for dihydrogen and drugs, applied in the field of medical technology, can solve problems such as not being effectively developed, and achieve the effects of convenient source of raw materials, high yield, and easy-to-obtain raw material sources.
CN101548971BInactive Publication Date: 2011-01-05WENZHOU MEDICAL UNIV +1
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Abstract
The invention relates to application of lignin flavanonol in preparation of antiviral drugs, particularly, the invention relates to a chemical compound as formula (I), (+-)-2-[2,3-dihydro-2-(3,5-dimethoxy-4-hydroxy phenyl)-3-hydroxymethyl-1,4-benzodioxane-5]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyrone-4-ketone, or use of its medicinal salt used for preparing drugs for repressing virus infectioncaused by herpes simplex virus HSV-1 and / or drugs for curing oral ulcer. The chemical compound is prepared by chemical synthesis, pharmacological experiments shows that, the chemical compound has powerful inhibitory action to the herpes simplex virus HSV-1, and the half inhibitory concentration value IC[50] is 39.41 mg / mL.
Description
Application of lignin dihydroflavonol in the preparation of drugs for inhibiting herpes simplex virus technical field The present invention relates to the technical field of medicine, in particular, the present invention relates to a lignin dihydroflavonol derivative, namely the compound (±)-2-[2,3-dihydro-2-(4-hydroxyphenyl)-3 -Hydroxymethyl-1,4-benzodioxane-5]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one or its druggable Use of salt for preparing medicine for inhibiting virus infection caused by herpes simplex virus HSV-1 and / or treating oral ulcer. Background technique Herpes simplex virus can be divided into two types: type I and type II. Type I herpes virus (HSV-1) mainly infects the skin, mucous membranes and organs above the waist. HSV-1 is mainly transmitted through close contact with the respiratory tract, skin and mucous membranes. 99% Inflammation and herpes of the oral mucosa, nasal vestibule, conjunctiva, throat, and herpes around the mouth are all caus...
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Patent Timeline
05 Jan 2011
Publication
CN101548971B
- IPC
- A61K31/357; A61P31/22; A61P1/04
- Inventors
- 李校堃; 龚景旭