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Mactra veneriformis extract, preparation method and application thereof

A technology of four-horned clams and extracts, which is applied in the field of four-horned clams extracts and can solve the problems of less research and development of medicines and health care products of the four-horned clams, etc.

Active Publication Date: 2012-01-11
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At home and abroad, the development and application of four-cornered clams mostly use software as raw materials to process canned food, condiments, feed additives, etc., while the research and development of medicine and health products for four-cornered clams with the goal of medicinal functions are less
The researches on the active substances of the four-cornered clam mostly focus on small molecular chemical components (such as taurine and EPA), and there are few reports on the research on its biologically active macromolecular extracts, such as proteins and polysaccharides
At present, there are no medicines and health products about clam extracts on the market

Method used

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  • Mactra veneriformis extract, preparation method and application thereof
  • Mactra veneriformis extract, preparation method and application thereof
  • Mactra veneriformis extract, preparation method and application thereof

Examples

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preparation example Construction

[0024] One, the preparation of four-cornered clam extract

[0025] During the period from July 2007 to June 2008, three-bellied clams were harvested at the aquaculture farm in Lvsigang Town, Qidong, Jiangsu every month, and the meat rate, protein and polysaccharide content of the harvested clams were measured. , it was concluded that the quality of clams harvested in June and July was the best. Based on this, it was determined that the three-bell-age clam quadrangularis harvested along the coast of Jiangsu in June-July was used as the product raw material to prepare the hypoglycemic clam quadrangularis extract. The following are specific implementation methods.

Embodiment 1

[0027] Take freshly harvested living clams, remove the shell, and obtain 5 kg of soft body raw materials, wash the mud and sand, drain and mince. Boiling water decoction repeated extraction 3 times, adding 10kg of water each time, decocting and extracting for 30 minutes each time, filtering with 200-mesh filter cloth, and collecting the filtrate. Centrifuge the decoction in a centrifuge at a speed of 4000rmp to obtain a supernatant, concentrate it to about 5L, add ethanol with a mass concentration of 95% after cooling to make the ethanol content of the system reach 50%, stir well, and stand at -10°C Precipitate for 12 hours, and filter with suction to obtain a white flocculent precipitate. The precipitate was dried in a vacuum oven at 60°C for 64 hours to obtain a light brown clam extract.

Embodiment 2

[0029] Take freshly harvested living clams, remove the shell, and obtain 5 kg of soft body raw materials, wash the mud and sand, drain and mince. Boiling water decoction repeated extraction 2 times, adding 15kg of water each time, decocting and extracting for 60 minutes each time, filtering with 200-mesh filter cloth, and collecting the filtrate. Centrifuge the decoction in a centrifuge at a speed of 4000rmp to obtain a supernatant, concentrate to about 5L, cool the concentrate and add ethanol with a mass concentration of 95% to make the ethanol content of the system reach 90%, stir well, and stand at -10°C Precipitate for 12 hours, and filter with suction to obtain a white flocculent precipitate. The precipitate was dried in an oven at 80°C for 48 hours to obtain a brown-yellow clam extract.

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Abstract

The invention relates to a mactra veneriformis extract which is prepared by the following method of taking the soft body part of the mactra veneriformis as a material, washing and grinding the material, adding water for decoction, filtering, then obtaining water decoction extracting solution, centrifuging the water decoction extracting solution,collecting supernatant fluid, concentrating, cooling,then adding ethanol for precipitating, filtering, obtaining an ethanol precipitate, drying and then obtaining the mactra veneriformis extract; and deproteinizing the mactra veneriformis extract to obtain purified mactra veneriformis extract which has glycemia-reducing, immune adjusting and liver-protecting functions. The invention also discloses the applications of the mactra veneriformis extracton preparation of medicaments or health care products simultaneously.

Description

1. Technical field [0001] The invention belongs to the field of natural medicines, and in particular relates to a four-cornered clam extract, its preparation method and its application in pharmacy. 2. Background technology [0002] Mactra quadrangularis, also known as square Mactra quadrangularis, white clam or square clam, commonly known as white clam, mud clam, cloth pigeon head, is a common marine mollusc, widely distributed in the coastal waters of the north and south of my country . Belongs to the mollusk door, petal branch class, true flap branch order, clam family. The shell is slightly quadrangular, the two shells are equal, the sides expand, and the shell surface is smooth and white. The ax foot is well developed, without silk, and lives in the sand of shallow sea. There are many tidal flats along the coast of Jiangsu, and the four-cornered clam is the dominant shellfish. Large-scale artificial breeding has been realized, and the output is as high as 80,000 tons p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/56A61P3/10A61P37/02A61P1/16A23L1/29A23L33/00A61K35/618
Inventor 吴皓王令充狄留庆常念程建明文红梅
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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