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Preparation method and technology of alliin reference substance

A technology of alliin and reference substances, which is applied in the field of preparation of alliin reference substances, can solve the problems of high price, difficulty, complicated extraction and purification process of alliin, and achieve the effect of simple extraction and purification process and low price

Active Publication Date: 2009-10-21
新疆胡蒜研究院(有限公司)
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  • Summary
  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

Therefore, the extraction and purification process of alliin is very complicated and difficult.
Only certain countries such as the United States can provide, but the price is expensive

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0010] Preparation of alliin reference substance by ethanol recrystallization: alliin raw material was recrystallized with 70-75% ethanol as solvent (solid-liquid ratio was 1:8-20), suction filtered and crystallized after 48h, washed with 70% ethanol, reduced at 60°C Dry under vacuum to obtain primary crystals with a melting point of 156.3-157.2°C and a content of 90-95%; secondary crystals: recrystallize again with 75-80% ethanol as a solvent (the ratio of solid to liquid is 1:20-30), after 24 hours Suction filtration, washing with 80% ethanol, vacuum drying under reduced pressure at 60°C to obtain secondary alliin crystals, melting point 160.0-161.0°C, content 95-98%; third crystallization: third recrystallization with 80% ethanol as solvent (material Liquid ratio is 1:30-40), suction filtration after 24 hours, washing with 90% ethanol, vacuum drying under reduced pressure at 60°C to obtain a high-purity alliin reference substance with a melting point of 162-163°C and a speci...

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Abstract

The invention relates to a preparation method and technology of alliin reference substance, which comprises the following steps of: first extracting alliin from fresh garlic; then preparing the alliin reference substance by using two methods: the first method is to prepare the alliin reference substance by ethanol recrystallization; and the second method is to prepare the alliin reference substance by acetone recrystallization; and finally determining the alliin physical constant, analyzing four spectrum, and determining the purity; if all the indicators thereof are eligible, the product complies with the 'alliin reference substance' required by the 'plant extract reference substance' regulated by the State Food and Drug Administration.

Description

Technical field [0001] The invention relates to a preparation method and process of an alliin reference substance, in particular to a preparation method and process of a reference standard substance necessary for quality control of garlic and its series products (including raw materials, extracts, health food and medicine). Background technique [0002] Alliin (S-allyl cysteine ​​sulfoxide) is the main sulfur-containing organic compound in the bulb of garlic (Allium sativum L.), which is white crystal or crystalline powder. There are four isomers of synthetic S-allyl cysteine ​​sulfoxide (Table 1). However, only one isomer is extracted from the natural plant garlic: (+) S-allyl-L-cysteine ​​sulfoxide (S-allyl-L-cysteine ​​sulfoxide), known as alliin . [0003] Because garlic bulbs contain a variety of alliin homologues, isomers and related substances, and their physical and chemical properties are similar. Therefore, the extraction and purification process of alliin is ve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C317/48C07C315/06
Inventor 李新霞陈坚朱瑾
Owner 新疆胡蒜研究院(有限公司)
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