Aporphine compound, medicinal composition thereof and application thereof

An apophine and compound technology, applied in the field of apophine compounds, can solve the problems of involuntary movements, monotonous stereotypes, etc.
CN101619040AInactive Publication Date: 2010-01-06SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
Publication Date
2010-01-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to an aporphine compound represented by general formula (I) or stereoisomer thereof, pharmaceutically acceptable salt or pharmaceutically acceptable solvate and medical application thereof. The compound can be used for preventing or treating diseases related with serotonin 1A receptors, wherein the diseases comprise central nervous system diseases, in particular schizophrenia, depression and movement disorder caused by Parkinson's resistant medicament. The invention also relates to a medicinal composition comprising the compound.
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Description

technical field

[0001] The present invention relates to apomorphine compounds which have activity on serotonin 1A receptors and are therefore useful in various therapeutic fields, especially in the treatment of diseases of the central nervous system, such as schizophrenia, depression and anti-parkinsonism Dyskinesia drug-induced movement disorders, etc. The present invention also relates to pharmaceutical compositions comprising the compounds described above. Background technique

[0002] 1. Five serotonin 1A receptors

[0003] Five serotonin (5-HT) is an important central neurotransmitter. The synthesis, storage, membrane uptake and metabolism of 5-HT together with the 5-HT receptor constitute the 5-HT nervous system. Currently, at least seven types of 5-HT receptors have been cloned, namely 5-HT 1 ~5-HT 7 . Some have several subtypes. Drugs acting on the 5-HT system are used to treat various mental diseases such as schizophrenia and depression, obesity, and sexual d...

Claims

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