Diagnostic method for immune state of chronic hepatitis B patient

A chronic hepatitis B, diagnostic method technology, applied in the field of medical diagnosis, can solve the problems of overuse, tissue damage and other medications, achieve less time-consuming, simple operation, improve and predict the effect of CHB treatment

Inactive Publication Date: 2010-01-13
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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Problems solved by technology

However, the existing technology lacks effective prompts for the immune status of patients with chronic h

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  • Diagnostic method for immune state of chronic hepatitis B patient
  • Diagnostic method for immune state of chronic hepatitis B patient
  • Diagnostic method for immune state of chronic hepatitis B patient

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[0020] The present invention will be further clarified below in conjunction with specific examples. It should be understood that these embodiments are only used to illustrate the present invention and not to limit the scope of the present invention. The experimental methods that do not indicate specific conditions in the following examples usually follow the conventional conditions or the conditions recommended by the manufacturer.

[0021] 1. Materials and methods

[0022] 1.1 Cases From September 2007 to February 2008, 45 clinically diagnosed patients with chronic hepatitis B (CHB) who were admitted to the Department of Infectious Diseases of Changhai Hospital were all in the immune clearance period (ALT≥2 times n.v). The diagnosis complied with the standards of the "Viral Hepatitis Prevention and Control Program" revised in 2000. All cases excluded other hepatitis virus infections, autoimmune hepatitis, alcoholic liver disease, etc., and did not receive any antiviral and immun...

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Abstract

The invention relates to the medical diagnosis technical field, in particular to a diagnosis method for immune state of chronic hepatitis B patient. The diagnosis method for immune state of a chronic hepatitis B (CHB) patient includes the following steps: collecting peripheral blood sample of a chronic hepatitis B patient and anti-freezing processing; detecting PD-1 of peripheral blood total CD8<+> T cell in the peripheral blood sample; and analyzing PD-1 single cell expression of the peripheral blood total CD8<+> T cell. The diagnosis method of the invention has good sensitivity and specificity, simple operation and less time consumption, and meanwhile the invention can provide important information for knowing immune state of patient in clinical and further can provide effective information for deciding and adjusting a treatment scheme in clinical CHB antivirus treatment and has far-reaching significance for improving and predicting CHB healing efficacy.

Description

technical field [0001] The invention relates to the technical field of medical diagnosis, in particular to a method for diagnosing the immune status of patients with chronic hepatitis B. Background technique [0002] Hepatitis B virus caused by HBV infection is a common and serious liver disease. More than 2 billion people have been infected with HBV, and 350 million people still carry HBV virus, 1 / 3 of which are in China. [0003] At present, the immunological mechanism of hepatitis B chronicity mainly includes: (1) immune tolerance formed by mother-to-child transmission or infection in early childhood; (2) viral gene integration into the host genome; (3) virus mutation, resulting in immune evasion ; (4) The virus infects the immune cells of the host, resulting in a decline in immune function. The chronicity of hepatitis B is related to the formation of immune tolerance, and is characterized by the low immune response of the body to HBV. The characteristics of the immune ...

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Application Information

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IPC IPC(8): G01N33/576
Inventor 梁雪松万谟彬
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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