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Analysis method for application of circRNAs in lung adenocarcinoma

An analysis method and technology of lung adenocarcinoma, applied in the field of biomedicine, can solve the problems of insufficient diagnosis and treatment, poor prognosis of lung adenocarcinoma, etc., achieve good sensitivity and specificity, and improve the effect of early diagnosis

Pending Publication Date: 2022-02-18
THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
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Problems solved by technology

Although lung adenocarcinoma has been extensively researched and developed, its diagnosis and treatment are still insufficient. Most patients are diagnosed in the middle and advanced stages with lymph node metastasis. Therefore, the prognosis of lung adenocarcinoma is not good.

Method used

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  • Analysis method for application of circRNAs in lung adenocarcinoma
  • Analysis method for application of circRNAs in lung adenocarcinoma
  • Analysis method for application of circRNAs in lung adenocarcinoma

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Embodiment Construction

[0029] The present invention will be described in further detail below in conjunction with the embodiments given in the accompanying drawings.

[0030] refer to Figure 1-10 as shown,

[0031] A method for analyzing the molecular mechanism and diagnosis of exosomal circRAPGEF5 in lung adenocarcinoma, comprising the following steps:

[0032] 1. If figure 1 As shown, the present invention analyzes differentially expressed circRNAs in lung adenocarcinoma tissue and paracancerous tissues through gene chips, and confirms circRAPGEF5 through RT-qPCR verification. Cytological experiments analyze that circRAPGEF5 promotes the proliferation and migration of lung adenocarcinoma cells by up-regulating the expression of ZEB1 , the molecular mechanism of invasion and EMT process, and further analyzed the differences in the expression of circRAPGEF5 in lung adenocarcinoma tissue and serum exosomes.

[0033] 2. In order to better illustrate the application of circRAPGEFF5 verified by the ...

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Abstract

The invention discloses an analysis method for application of circRNAs in lung adenocarcinoma, and the method comprises the following steps of: acquiring differentially expressed circRNAs in lung adenocarcinoma, and acquiring high-expression circRAPGEF5; and analyzing the influence of circRAPGEF5 on proliferation, apoptosis, migration and invasion of lung adenocarcinoma cells. The invention lays a foundation for early diagnosis of lung adenocarcinoma, preparation of lung adenocarcinoma targeted drugs and preparation of products for judging the disease risk of lung adenocarcinoma patients.

Description

technical field [0001] The invention relates to biomedicine, in particular to an analysis method of circRNAs in the diagnosis mechanism of lung adenocarcinoma. Background technique [0002] Lung adenocarcinoma is characterized by high heterogeneity, complex clinical response, and poor prognosis. Major causes of lung adenocarcinoma progression include lack of preventive measures, late diagnosis, extremely variable tumor environment, multidrug resistance, and metastatic spread. Although lung adenocarcinoma has been extensively researched and developed, its diagnosis and treatment are still insufficient. Most patients are diagnosed in the middle and advanced stages with lymph node metastasis. Therefore, the prognosis of lung adenocarcinoma is not good. Invasion and metastasis are the main causes of treatment failure in lung adenocarcinoma. Epithelial-mesenchymal transition occurs in the early stages of metastasis, in which epithelial cells acquire a mesenchymal phenotype, the...

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Application Information

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IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/178C12Q2600/158C12Q2600/118
Inventor 王瑜敏周慧新陈洁姜丰胡丽娟章帆杨翔
Owner THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
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