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Preparation method of traditional Chinese medicine preparation for dissipating breast lumps

A milk mass elimination and preparation technology, which is applied in the direction of medical formula, drug combination, medical preparations containing active ingredients, etc., can solve the problems of patients who cannot meet the needs of oral medicine, save time, save energy, and improve economic benefits Effect

Inactive Publication Date: 2010-05-05
XIAN BEILIN PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The retrieved Rukuaixiao related patent application numbers are 200510034592.X and 200510032430.2, etc. The preparation methods of the solid preparations in the cream powder of the 2005 edition of "Chinese Pharmacopoeia" are adopted. In addition, most of the current Rukuaixiao preparations are oral preparations , can not satisfy some patients who cannot take medicine orally, the present invention also provides a preparation method of patch besides the preparation method of oral preparation

Method used

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  • Preparation method of traditional Chinese medicine preparation for dissipating breast lumps
  • Preparation method of traditional Chinese medicine preparation for dissipating breast lumps

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preparation example Construction

[0023] Preparation of reference substance solution Take an appropriate amount of Danshensu sodium reference substance, weigh it accurately, add 5% oxalic acid solution to make a solution containing 48 μg per 1 ml (equivalent to 43 μg per 1 ml of danshensu), to obtain final product;

[0024] Preparation of the test solution Take 0.3g cream powder, accurately weighed, put in a centrifuge tube, add 2ml of water and 1.5g of neutral alumina (100-200 mesh), stir well, wash with water twice, 20ml each time, centrifuge (rotating speed is 3000 revolutions per minute), discard the aqueous solution, then stir and extract with 5% oxalic acid solution for 3 times, 8ml each time, centrifuge, combine the 5% oxalic acid solution, put it in a 25ml measuring bottle, add 5% oxalic acid solution to the mark, Shake well, filter, and take the filtrate to obtain;

[0025] Determination method Precisely draw 10 μl each of the reference substance solution and the test solution, inject it into the liqu...

Embodiment 1

[0034] Weigh the processed pure medicinal materials: 825g of orange leaves, 825g of salvia miltiorrhiza, 550g of wangbuliuxing, 550g of toosendan, 550g of earthworm, and 550g of saponins. Dilong and Wangbuliuxing were refluxed twice with 70% ethanol, the first time was 5 times the amount of 70% ethanol, refluxed for 2 hours, the second time was 4 times the amount of 70% ethanol, refluxed for 1 hour, and collected The reflux liquid was combined and filtered, and the ethanol was recovered to obtain the alcohol extract, which was set aside; the remaining four medicinal materials were decocted twice, adding 10 times the amount of water for the first time, and 8 times the amount of water for the second time, decocting for 1 hour each time, and combining Decoction, filter, concentrate the filtrate to an extract with a specific gravity of 1.25-1.30 (60°C), let it cool, combine with the above-mentioned standby alcohol extract, adjust the ethanol content to 70%, stir evenly, let stand, ...

Embodiment 2

[0038] Weigh the processed pure medicinal materials: 825g of orange leaves, 825g of salvia miltiorrhiza, 550g of wangbuliuxing, 550g of toosendan, 550g of earthworm, and 550g of saponins. Dilong and Wangbuliuxing were refluxed twice with 70% ethanol, the first time was 5 times the amount of 70% ethanol, refluxed for 2 hours, the second time was 4 times the amount of 70% ethanol, refluxed for 1 hour, and collected The reflux liquid was combined and filtered, and the ethanol was recovered to obtain the alcohol extract, which was set aside; the remaining four medicinal materials were decocted twice, adding 10 times the amount of water for the first time, and 8 times the amount of water for the second time, decocting for 1 hour each time, and combining Decoction, filter, concentrate the filtrate to an extract with a specific gravity of 1.25-1.30 (60°C), let it cool, combine with the above-mentioned standby alcohol extract, adjust the ethanol content to 70%, stir evenly, let stand, ...

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Abstract

The invention belongs to the technical field of Chinese traditional medicine and in particular to a preparation method of a traditional Chinese medicine preparation for dissipating breast lumps. At present, the majority of all the like products in the market is oral preparations and has more complex preparation technology. The traditional Chinese medicine preparation for dissipating breast lumps is composed of citrus deliciosa, radix salviae miltiorrhizae, cowherb seed, toosendan fruit, earthworm and Chinese honeylocust spine, and has the functions of activating blood, dissolving stasis, dissipating breast lumps, soothing the liver and regulating the flow of vital energy. The cream powder prepared by the spray drying technology provided by the invention contains more danshensu than the cream powder prepared by the vacuum drying technology. In addition, the invention provides an external patch which effectively satisfies the requirements of certain patients who can not orally take medicines and achieves the treating goal through the percutaneous absorption principle.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a preparation method of a traditional Chinese medicine Rukuaixiao preparation. Background technique [0002] The Rukuaixiao Tablets recorded in the 2005 edition of "Chinese Pharmacopoeia", and similar drugs include Rukuaixiao Capsules (soft capsules), Rukuaixiao Granules, Rukuaixiao Oral Liquid and other oral preparations. Composed of orange leaves, saponins, toosendan, salvia miltiorrhiza, wangbuliuxing, and earthworm in a certain proportion, it is mainly used to treat breast diseases, and at the same time, it has the functions of promoting blood circulation, removing blood stasis, soothing liver and regulating qi. The retrieved Rukuaixiao related patent application numbers are 200510034592.X and 200510032430.2, etc. The preparation methods of the solid preparations in the cream powder of the 2005 edition of "Chinese Pharmacopoeia" are adopted. I...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61P15/14A61K35/64A61K35/62
Inventor 黄小华付彬石丽
Owner XIAN BEILIN PHARMA
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