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Compound vitamin nanoemulsion

A technology of compound vitamins and nanoemulsions, which is applied in the fields of pharmaceutical formulations, emulsion delivery, metabolic diseases, etc. It can solve problems such as turbidity, poor compatibility, and low content of active ingredients, and achieve the effects of improving physical fitness, shortening the course of treatment, and improving solubility

Active Publication Date: 2010-08-11
山东恩诺基生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the liquid multidimensional produced by these raw materials combined with this process can overcome the defects of solid preparations to some extent, there are still some problems in the following aspects: the compatibility of the system is poor, and vitamins, minerals, and water interfere with each other, resulting in The content of active ingredients in the product is low and the types are not rich enough; the particle size of latex particles is large, which is easy to block the nipple of the drinking fountain, creating suitable breeding conditions for pathogenic microorganisms; the product has poor stability, and the validity period is generally 12 months. It can be reduced to 65% of the marked amount, and the color tends to become darker and turbid when exposed to light

Method used

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  • Compound vitamin nanoemulsion
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] like figure 2 As shown, every 1000ml compound vitamin nanoemulsion is prepared by the following method:

[0031] 1) Prepare the oil phase: take 22g of benzyl alcohol and heat it to 30°C, add vitamin D to the benzyl alcohol at this temperature 3 4.8 million IU, stir to dissolve, add vitamin A 18 million IU, vitamin E 7.5g, then add 50g AEO-9 and 200g Tween-80, stir well;

[0032] 2) Stop heating, add water for injection to dilute the oil phase, then add the following water-soluble active ingredients and mix well: Vitamin B 1 1g, vitamin B 2 0.2g, vitamin B 6 1.6g, three needles extract 5g, lysine 15g, methionine 15g;

[0033] 3) Add water for injection to dilute to 1000ml.

[0034] After passing the inspection, the product is filtered, canned, sealed, packaged and put into storage after passing the inspection.

Embodiment 2

[0036] Each 1000ml compound vitamin nanoemulsion is prepared by the following method:

[0037] 1) Preparation of the oil phase: Mix 42g of AEO-4 with 180g of Tween-80, heat up to 60°C and mix fat-soluble active ingredients (vitamin A 12 million IU, vitamin D 3 3 million IU, vitamin E 5g) were added therein, and then 19g of benzyl alcohol was added, fully mixed to form an oil phase;

[0038] 2) Stop heating, add water for injection to dilute the oil phase, then add the following water-soluble active ingredients and mix well: Vitamin B 1 3g, vitamin B 2 0.7g, vitamin B 6 2.5g, three needles extract 18g, lysine 30g, methionine 10g;

[0039] 3) Add 5g of n-butanol to the system, stir evenly, add water for injection to dilute, and dissolve to 1000ml.

Embodiment 3

[0041] Each 1000ml compound vitamin nanoemulsion is prepared by the following method:

[0042] 1) Preparation of oil phase: Mix 35g of AEO-9, 150g of Tween-80, and 16g of benzyl alcohol and heat up to 45°C, add 1.8 million IU of vitamin D 3 , after dissolving, add vitamin A 6 million IU, vitamin E 2.5g, fully mix to form an oil phase;

[0043] 2) Stop heating, add water for injection to dilute the oil phase, then add the following water-soluble active ingredients and mix well: Vitamin B 1 4g, vitamin B 2 1.0g, vitamin B 6 4.2g, three needles extract 25g, lysine 45g, methionine 15g;

[0044] 3) Add water for injection to dilute to 1000ml.

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Abstract

The invention relates to compound vitamin nanoemulsion belonging to the technical field of pharmacy. Every 1000 ml of nanoemulsion is prepared by the method comprising the following steps of: fully mixing 35-50g of AEO-9 or AEO-4, 150-200g of tween-80, 16-22g of phenylcarbinol and fat-soluble active ingredients at 30-60 DEG C to prepare an oil phase; adding water to dilute the oil phase; adding water-soluble active ingredients; evenly mixing; adding water to dilute and confirm solution contents and adding water to dilute to a volume, wherein the fat-soluble active ingredients comprise 6-18 million IU of vitamin A, 1.8-4.8 million IU of vitamin D3 and 2.5-7.5g of vitamin E, and the water-soluble active ingredients comprise 1-4g of vitamin B1, 0.2-1.0g of vitamin B2, 1.6-4.2g of vitamin B6, 5-25g of barberry extractive and 30-60g of amino acid. The product is clear and transparent, has good stability, slow-release effect, persistent drug effect, great specific surface area of nanoemulsion particles and good system compatibility, can obviously improve the drug absorption rate and the bioavailability and can be compounded with various useful elements besides vitamins.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to an animal drug additive-compound vitamin nanoemulsion, which can be taken orally or made into an injection. Background technique [0002] Vitamins are essential organic compounds in the metabolism of humans and animals, and play an important role in the body's metabolism, growth and development, and maintenance of body health. If there is a long-term lack of certain vitamins, it will cause physiological dysfunction and certain diseases. However, the body cannot synthesize vitamins by itself or synthesizes a small amount, so it needs to be obtained from food or vitamin supplements. [0003] At present, the multidimensional products on the market are still mainly solid preparations, and there is a tendency to develop into liquid dosage forms: using solid multidimensional premixes to supplement vitamins for livestock and poultry usually requires feeding with mixing mat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/29A61K9/107A61P3/02A61K31/593A61K31/525A61K31/51A61K31/4415A61K31/355A61K31/07A61K31/375A61K31/714A61K31/197A61K31/519A61K31/198
Inventor 张光辉陈鹏举
Owner 山东恩诺基生物工程有限公司
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