High purity fasudil hydrochloride compound

Abstract

The invention relates to high purity fasudil hydrochloride compound; the method can obtain high purity fasudil hydrochloride finished goods and belongs to the technical field of medicine. The purity of the fasudil hydrochloride is greatly increased by acid-base reaction, silicagel column elution and activated carbon adsorption. The method has simple technique, low cost and high yield and is suitable for industrialization production.

Description

A high-purity fasudil hydrochloride compound technical field The invention relates to a fasudil hydrochloride compound, through which high-purity fasudil hydrochloride can be obtained, and belongs to the technical field of medicine. Background technique Fasudil hydrochloride, chemical name is hexahydro-1-(5-isoquinolinesulfonyl)-1H-1,4-diazepine hydrochloride, molecular formula C14H17N3O2S·HCl, molecular weight 327.83, as the following diagram (I) Compounds of structure: Fasudil hydrochloride is a protein kinase inhibitor, that is, an intracellular calcium ion antagonist. It dilates blood vessels and inhibits vasospasm by blocking the phosphorylation of myosin light chain, the final stage of the vasoconstriction process. It is clinically suitable for improving and preventing cerebral spasm after subarachnoid hemorrhage and the symptoms of cerebral ischemia caused by it. The preparation method of fasudil hydrochloride is seldom reported at home and abroad, and only Ti...

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Problems solved by technology

The preparation method of Fasudil hydrochloride is seldom reported at home and abroad, and only Tianjin Hongri Pharmaceutical Co., Ltd. is the exclusive manufacturer in China. The purity of the product is poor, which leads to substandard quality of the preparation and affects clinical application.

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