Use of a combination of hesperidin and of a microorganism for influencing the barrier function of the skin

A technology of skin barrier and hesperidin, applied in the field of combination, can solve the problem that the combination of hesperidin and microorganisms is not described, etc.

Inactive Publication Date: 2013-10-09
LOREAL SA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0058] But the combination of hesperidin and microbes has never been described

Method used

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  • Use of a combination of hesperidin and of a microorganism for influencing the barrier function of the skin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0208] Example 1 - Evaluation of the effect of the combination according to the invention on the barrier function of reconstituted skin

[0209] For direct application to skin models, the first step in all promotional behaviors is the change of nutrients (hereinafter referred to as prebiotic conditioned medium) after ingestion (phase A).

[0210] Subsequently, the co-culture medium stimulated by Lactobacillus paracasei in the basolateral region was taken, and then its combination with the most important metabolite of hesperidin, hesperetin-7 glucuronide (Hes7Glu), was tested in vitro for its effect on Model the effects of barrier function (Phase B).

[0211] A - Preparation of prebiotic conditioned medium

[0212] An intestinal barrier model was established (comprising a human intestinal cell line (Caco-2) co-cultured with human leukocytes in a "transwell" cell co-culture system [Haller D, 2000]).

[0213] The model consists of two separate cultures:

[0214] - Culturi...

Embodiment 2

[0246] Example 2 : Single dose gel

[0247] active ingredient

[0248] water

[0249] Available in doses of 200-400ml per day .

Embodiment 3

[0250] Example 3 :capsule

[0251]

[0252] Take 1-3 of these capsules per day.

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Abstract

Cosmetic use of hesperidin (I) or its derivatives in combination with at least a microorganism (probiotic), one of its fractions or metabolites, as an agent to prevent reduction of barrier function of skin, strengthen barrier function of skin, and / or strengthen protection of skin against external aggression, is claimed. - ACTIVITY : Dermatological; Tranquilizer; Antipruritic; Nootropic. - MECHANISM OF ACTION : None given.

Description

technical field [0001] The present invention relates to the use, in particular as a cosmetic, of a combination intended to prevent a reduction and / or to strengthen the barrier function of the skin, in particular to prevent and / or treat related disorders, especially due to Those disorders caused by dryness. [0002] The present invention also relates to the prevention and / or treatment of signs of skin aging and / or photoaging, especially those induced or exacerbated by pollution. Background technique [0003] Human skin is composed of two layers, a deep layer (dermis) and a superficial layer (epidermis). [0004] The skin constitutes a barrier against external aggressions, especially chemical, mechanical or infectious aggressions, whereby numerous defense reactions against environmental factors (climate, UV rays, smoking, etc.) and / or host-host commensal organisms such as microorganisms take place therein. This property, known as barrier function, is primarily provided by th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/99A61Q19/00A61K8/60A61Q19/08A61K35/747
CPCA61K8/602A61K35/747A61K9/4858A61Q19/08A61K9/0014A61K45/06A23L1/3002A61K36/062A23Y2220/63A23V2002/00A61Q19/007A23L1/3014A61K8/31A61K9/0095A61K31/7048A61K8/99A23L33/105A23L33/135A61P17/00Y02A50/30A23V2400/165A61K2300/00A23V2200/302A23V2200/318A23V2200/3204A23V2250/206A23V2250/21164A23V2250/708
Inventor 欧特瑞·古昂斯伊萨布莱·卡斯蒂尔
Owner LOREAL SA
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