Carveol ester derivative and percutaneous absorption preparation containing same

Abstract

The invention belongs to the technical field of medicines, discloses a carveol ester derivative and a percutaneous administration preparation containing the derivative, and the structure formula thereof is shown in the specification. The derivative comprises saturated and unsaturated fatty acid carveol ester, wherein fatty acid reacts with carveol ester under the catalytic action of p-toluenesulfonic acid to directly form ester, and anhydrous cyclohexane is taken as a solvent. The carveol ester derivative can be taken as a transdermal enhancer for external preparations such as patch, poultice, ointment, gel and the like, thus improving the percutaneous absorptive amount of medicines, and having higher safety, lower irritation and better medicinal penetration capacity.

Description

technical field The invention belongs to the technical field of medicine, relates to a class of carverol ester derivatives and transdermal absorption preparations containing the derivatives, in particular to 8 carverol ester derivatives, including saturated and unsaturated fatty acid carverol esters : heptanoic acid, caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid carveyl ester and oleic acid carveyl ester, its preparation method and in transdermal preparation (patch, Babu formulations, ointments, gels, creams, etc.). Background technique Most of the terpenoid accelerators are derived from natural products (volatile oils). They have the advantages of strong penetration-promoting activity, low toxicity, low irritation, and penetration-promoting effects on both hydrophilic and lipophilic drugs. They have become domestic and foreign percutaneous absorption accelerators. One of the hotspots of research. However, the volatility of terpenoids ...

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