Method for synthesizing thiazole derivatives

Abstract

The invention discloses a method for synthesizing thiazole derivatives, comprising the following steps: 1) providing a mixture containing a compound with the general formula (II) and a compound with the general formula (III) and ensuring the mixture to act under minus 40-160 DEG C, wherein the mole ratio of the compound with the general formula (II) is 0.3-3.0 times that of the compound with the general formula (III); and 2) ensuring the solution in the step 1) to directly act with water under minus 40-160 DEG C without separation, thus obtaining the thiazole derivatives shown in the general formula (I). The method is shorter in synthesis route, higher in yield, lower in cost, low in raw material toxicity and environmental pollution and more convenient and easier in aftertreatment of the products, can obtain the thiazole derivatives with higher purity and is especially suitable for industrial production of the thiazole derivatives in mass.

Description

technical field The present invention relates to a synthesis method of thiazole derivatives, in particular to a synthesis method of thiazole derivatives represented by general formula (I), including 4-formaldehyde thiazole. Background technique Thiazole derivatives are widely used in medicine, spices and food industry. e.g. vitamin B 1 The molecule contains the structure of thiazole ring; thiazole derivatives are also well known as a class of important spices; in the field of medicine, clomethiazole (Clomethiazole) is a sedative and hypnotic drug, which has been clinically used abroad for many years, and was approved by the British Pharmacopoeia records, thiazofurine (Tiazofurine) is also used as an antineoplastic drug. Studies in recent years have further shown that thiazole derivatives display a variety of pharmaceutical uses and biological activities. GlaxoSmithKline (GlaxoSmithKline) discloses the patent [GLAXO GROUP LIMITED, WO 2004 / 060889 (2004)] that thiazole de...

AI Technical Summary

Problems solved by technology

As a professional in the equivalent technical field, it can be understood that the synthesis of thiazole aldehydes by halides is obviously long and requires an intermediate step through halides; Low, and it is difficult to post-process after the reaction, and it is difficult to obtain high-purity products