Novel quasi-physiological pulsating flow environment arterial blood vessel tissue engineering reactor

A technology for arterial blood vessels and tissue engineering, applied in the fields of cell culture and tissue engineering, which can solve the problems of high motor power and other parameters, complex structures, etc.
CN101974423AActive Publication Date: 2011-02-16BEIHANG UNIV +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
BEIHANG UNIV
Publication Date
2011-02-16

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Abstract

The invention relates to a novel quasi-physiological pulsating flow environment arterial blood vessel tissue engineering reactor. The reactor comprises a liquid storage device 27, a liquid driver 21 and a blood vessel tissue dynamic culture chamber 25 which are sequentially connected through a fluid pipeline to form a fluid circulation loop, and a pulsation generator 24, wherein the liquid driver21 drives a liquid culture medium to circularly flow; the pulsation generator 24 forms the pulsation of the circularly flowing liquid culture medium and comprises a pulsation chamber 241 which is a closed chamber with fixed volume, a closed piston 244 in the pulsation chamber 241, a linear steeping motor 243 and a pull rod 242; the pull rod connects the closed piston 244 with a driving shaft of the linear stepping motor 243; and the closed chamber is communicated with the fluid pipeline above the culture chamber 25.
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Description

technical field

[0001] The invention relates to the fields of cell culture and tissue engineering, and more particularly relates to a vascular tissue engineering reactor. Background technique

[0002] In the field of tissue engineering, tissue engineering bioreactor is an important technical means to study the influence of different environmental factors (physical and biochemical factors) on the three-dimensional functional culture of specific cells and tissues. Automation, online monitoring, etc.), making tissue engineering a key link in the process of entering standard industrial scale production and clinical application from the laboratory. Therefore, targeted research and development of advanced bioreactors for tissue engineering is of great significance to the development of tissue engineering.

[0003] So far, autograft, allogeneic blood vessels, xenograft blood vessels, and artificially synthesized blood vessels cannot become ideal arterial blood vessel substitutes (...

Claims

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