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Compound for inhibiting growth of tubercle bacillus and preparation method thereof

A technology of Mycobacterium tuberculosis and a compound, which is applied in the field of compounds for inhibiting the growth of Mycobacterium tuberculosis and its preparation, and can solve the problems of unclear specific target sites and the like

Inactive Publication Date: 2011-04-06
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The chemical name of SQ109 is N-adamantyl-2-yl-N'-(3,7-dimethylocta-2,6-diene)-ethane-1,2-diamine, and its mechanism of action may be As a cell wall inhibitor, induces the promoter Rv0341, but the specific target of its action is not clear

Method used

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  • Compound for inhibiting growth of tubercle bacillus and preparation method thereof
  • Compound for inhibiting growth of tubercle bacillus and preparation method thereof
  • Compound for inhibiting growth of tubercle bacillus and preparation method thereof

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Abstract

The invention relates to a compound for inhibiting the growth of tubercle bacillus and a preparation method thereof, belonging to the field of chemical synthesis. The invention provides 1-ethyl-4-hydroxy-2-oxygen-N'-trideformoxyl-1,2-dihydroquinoline-3-formylhydrazine with the structure of general formula (I) or pharmaceutically acceptable nontoxic salt thereof aiming at more and more serious epidemic situation of tuberculosis and the occurrence of multiple-drug resistant tuberculosis. In vitro tubercle bacillus inhibition tests verify that the compound of the invention can effectively inhibit the growth of tubercle bacillus, the MIC (Minimal Inhibitory Concentration) range is 0.4-2 mu g / ml, and moreover, the compound also has obvious inhibition effects on the growth of multiple-drug resistant tubercle bacillus in clinic.

Description

technical field The invention belongs to the field of chemical synthesis, and relates to a compound for inhibiting the growth of Mycobacterium tuberculosis and a preparation method thereof. Background technique Tuberculosis is a chronic respiratory infectious disease caused by Mycobacterium tuberculosis. According to the survey, the number of deaths caused by tuberculosis currently ranks first in the number of deaths caused by a single infection factor in the world. With the application of chemotherapy drugs, tuberculosis has been effectively controlled. However, affected by the prevalence of human immunodeficiency virus (HIV) infection and the increase of multidrug-resistant Mycobacterium tuberculosis infection, the tuberculosis epidemic has rebounded significantly. The current epidemic situation of tuberculosis in my country is very serious. It ranks second in the world after India. According to the analysis of the latest national tuberculosis epidemiological sampling ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D215/56A61K31/4704A61P31/06
Inventor 王洪海张雪莲郑保富陆静宁
Owner FUDAN UNIV
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