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New application of basidiomycetes or extract thereof (3-trametenloic acid B)

A technology of hydropinesolic acid and Trametes thaliana is applied in the directions of medical preparations containing active ingredients, drug combinations, medical raw materials derived from fungi, etc., to achieve the effect of preventing diabetes and clear efficacy.

Inactive Publication Date: 2011-04-27
郭志勇
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are no relevant literature reports on the use of Trametes major albus and its extracts and 3-hydropinemic acid B in the treatment of diabetes

Method used

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  • New application of basidiomycetes or extract thereof (3-trametenloic acid B)
  • New application of basidiomycetes or extract thereof (3-trametenloic acid B)
  • New application of basidiomycetes or extract thereof (3-trametenloic acid B)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1 Health food preparation of the present invention

[0020] solid culture

[0021] Use corn flour or rice flour or soybean flour or wheat flour, particle size: pass through a 10-100 mesh sieve, add 20%-70% water, inoculate wild Trametes albus mycelium after autoclaving, and cultivate at 20-32°C for 10-20 days. Dried for consumption or crushed into capsules.

[0022] Quality control method: 3-Hydropine acid B content is greater than 0.05%

[0023] How to eat: cook porridge and rice.

[0024] Dosage: 10-100g each time, 2-3 times a day, 2-10 capsules each time, 2-3 times a day.

[0025] liquid culture

[0026] Use one of the following media, inoculate after autoclaving, and shake at a speed of 30-250 rpm. Cultivate at 20-32°C for 5-15 days, centrifuge after the end of the cultivation, dry the hyphae, weigh them, pulverize them, and pack them into capsules.

[0027] Formula 1: glucose 1-10%, peptone 1-5%, gypsum 0.2g-1%

[0028] Formula 2: corn syrup 10-50...

Embodiment 2

[0034] Embodiment 2 The quality control method of Trametes maxima of the present invention

[0035] After the sample was crushed, passed through an 80-mesh sieve, 0.1 g was accurately weighed, and 50 ml of acetone was added for ultrasonication for 30 min. Continue to sonicate for 30 minutes after standing for 1 hour. Acetone compensates for lost weight. Draw the sample solution and filter it with a 0.45 μm membrane. Acetonitrile / water (95:5) was used as the mobile phase, the flow rate was 1ml / min, the injection volume was 10μl, and the detection wavelength was 214nm for high performance liquid chromatography analysis.

[0036] 1. Chromatographic conditions

[0037] Chromatographic column YMC-Pack AQ C18, 250×4.6mm, 5μm, the mobile phase is 95% acetonitrile-water system, the injection volume is 10μl, the column temperature is 25℃, the flow rate is 1.0ml / min, and the detection wavelength is 214nm. Under this condition, the analyte components can achieve baseline separation. ...

Embodiment 3

[0057] Embodiment 3 Determination of the content of 3-hydropinic acid B in different ethanol concentration extracts of Trametes maxima of the present invention

[0058] The Trametes albus prepared was extracted by ethanol reflux with different concentrations, and the weight percentage of 3-hydropinemic acid B was determined, the results are shown in Table 3:

[0059] table 3

[0060] Different concentrations of ethanol

3-Hydropinemic acid B

60％

0.1％

70％

0.6％

80％

2％

95％

5.71％

[0061] The above test proves that the content of 3-hydropinemic acid B is the highest when 95% ethanol is used to extract Trametes maxima.

[0062] Prove beneficial effect of the present invention by pharmacodynamic test below.

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Abstract

The invention provides a new application of basidiomycetes and extract thereof (3-trametenloic acid B), particularly the application in treating or / and preventing diabetes. The medicine provided by the invention has the advantages of definite medicine effect and high safety, and provides a new medicine option for clinical use.

Description

technical field [0001] The present invention relates to the new application of Trametes macrophage or its extract and 3-hydropinate B. It belongs to the field of medicine. Background technique [0002] Trametes lactinea (Berk.) Pat. is a polyporaceae fungus, basidiocarp is annual, sessile, corky. It grows on the wood of live-leaf trees and is distributed in China, Malaysia, Indonesia, Philippines, Pakistan, India, Sri Lanka, Australia and other countries. As a seed germination fungus of Gastrodia elata and other Orchidaceae, Trametes grandis has certain economic value, but there are few wild resources of Trametes grandis, which cannot meet the needs of its development and utilization. At present, the artificial culture method of Trametes maxima has been reported in the literature, such as: Tan Menghua, etc., optimization of the artificial culture conditions of Trametes maxima, Shizhen Guoyi Guoyao, Volume 19, No. 2, 2008; patent application number: 200810046969.7, inventio...

Claims

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Application Information

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IPC IPC(8): A61K36/06A61K31/575A61P3/10
Inventor 郭志勇邓改改汪鋆植邹坤王星琴程凡陈剑峰
Owner 郭志勇
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