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Anti-tumor medicament for promoting tumor cell senescence and preparation method thereof

A technology of anti-tumor drugs and tumor cells, applied in anti-tumor drugs, drug combinations, pharmaceutical formulations, etc.

Active Publication Date: 2011-11-16
LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report of traditional Chinese medicine that promotes tumor cell senescence. It is of great significance to develop traditional Chinese medicine that has the effect of promoting tumor cell senescence. The quality of life of cancer patients, prolonging the survival of cancer patients

Method used

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  • Anti-tumor medicament for promoting tumor cell senescence and preparation method thereof
  • Anti-tumor medicament for promoting tumor cell senescence and preparation method thereof
  • Anti-tumor medicament for promoting tumor cell senescence and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Weigh 3000g of vine pear root, 1000g of black nightshade, 1500g of snakeberry, 1200g of Atractylodes macrocephala, 1500g of poria cocos, 3000g of coix seed, 1000g of mistletoe, 3000g of banzhilian, and decoct them twice under pressure, add 6 times of water for the first time, soak After 30 minutes, extract, filter, and extract the filter residue with 4 times the amount of water, the second extraction time is 2 hours, combine all the filtrates, refrigerate for 24 hours, filter, the filtrate is concentrated into an extract, and its specific gravity is measured at room temperature as 1.20 -1.25, slowly add 3 times the amount of 95% ethanol under stirring, refrigerate for 24 hours, separate the supernatant, recover the ethanol until it has no alcohol smell, and concentrate under reduced pressure at 60°C to form an extract, store it at 50-60°C When measuring its relative density is 1.25-1.30, add appropriate auxiliary materials, granulate, granulate, and get final product.

Embodiment 2

[0041]Weigh 2500g rattan pear root, 2000g black nightshade, 1000g snakeberry, 1000g Atractylodes macrocephala, 1000g poria cocos, 2000g coix seed, 900g mistletoe, 4000g banzhilian, and decoct them twice under pressure, add 9 times of water for the first time, soak After 30 minutes, extract, filter, and extract the filter residue with 3 times the amount of water, the second extraction time is 3 hours, combine all the filtrates, refrigerate for 24 hours, filter, the filtrate is concentrated into an extract, and its specific gravity is measured at room temperature as 1.20 -1.25, slowly add 2 times the amount of 95% ethanol under stirring, refrigerate for 24 hours, separate the supernatant, recover the ethanol until it has no alcohol smell, and concentrate under reduced pressure at 50°C to form an extract, store it at 50-60°C When measuring its relative density is 1.25-1.30, add appropriate auxiliary materials, granulate, granulate, and get final product.

Embodiment 3

[0043] Weigh 1500g rattan pear root, 1000g black nightshade, 1200g snakeberry, 1600g Atractylodes macrocephala, 1500g poria cocos, 3000g coix seed, 1500g mistletoe, 3000g banzhilian, decoct twice under pressure, add 7 times of water for the first time, soak After 30 minutes, extract, filter, and extract the filter residue with 4 times the amount of water, the second extraction time is 2 hours, combine all the filtrates, refrigerate for 24 hours, filter, the filtrate is concentrated into an extract, and its specific gravity is measured at room temperature as 1.20 -1.25, slowly add 5 times the amount of 95% ethanol under stirring, refrigerate for 24 hours, separate the supernatant, recover the ethanol until it has no alcohol smell, and concentrate it under reduced pressure at 70°C to form an extract, store it at 50-60°C When measuring its relative density is 1.25-1.30, add appropriate auxiliary materials, granulate, granulate, and get final product.

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PUM

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Abstract

The invention discloses an anti-tumor medicament for promoting tumor cell senescence, which is prepared from the following raw medicaments in part by weight: 10 to 30 parts of yangtao actinidia root, 10 to 30 parts of black nightshade herb, 10 to 20 parts of mockstrawberry, 6 to 16 parts of large-headed atractylodes rhizome, 10 to 30 parts of tuckahoe, 10 to 30 parts of coix seed, 9 to 30 parts of mistletoe and 10 to 40 parts of barbed skullcap herb. The invention provides the anti-tumor medicament with a function of promoting tumor cell senescence. In addition, the invention also discloses apreparation method for granules of the medicament.

Description

technical field [0001] The invention relates to an antitumor drug for promoting tumor cell aging and a preparation method of the drug. Background technique [0002] Cell senescence refers to a relatively stable state that cells enter after irreversibly withdrawing from the cell cycle and losing their ability to proliferate. Senescent cells no longer proliferate, but maintain metabolic activity. At present, it is found that there are two forms of cellular senescence: replicative senescence and premature senescence. Premature senescence refers to the occurrence of cells under the stimulation of non-telomere signals, which has nothing to do with the length of telomeres and the number of proliferation generations, so it is called premature senescence. senescence. In gene models such as Pten, BRAFE600, K-rasV12, and Suv39h1, it has been confirmed that premature aging of cells is an intrinsic anti-cancer mechanism of cells, which plays an important role as a barrier in the format...

Claims

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Application Information

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IPC IPC(8): A61K36/8994A61K9/16A61P35/00
Inventor 胡兵沈克平安红梅史秀峰
Owner LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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