Medicine for relieving cough and asthma and preparation method thereof

A technology for relieving cough, relieving asthma and medicine, applied in the field of Chinese patent medicine, can solve the problems of poor quality controllability, large dosage of medicine, mixed active substances and non-active substances, etc., and achieves the effect of excellent medicine effect and reduced dosage.

Inactive Publication Date: 2011-05-11
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, since Sanao Decoction is used in the form of water decoction or raw medicinal materials, although it has been clinically proven to have a good curative effect, it also has a large dosage, mixed active substances and a large number of inactive substances, and it is difficult to study pharmacological effects. Disadvantages such as poor control

Method used

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  • Medicine for relieving cough and asthma and preparation method thereof
  • Medicine for relieving cough and asthma and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] 1. Preparation of ephedra total alkaloid extract and bitter almond extract

[0052] 1. Preparation of Ephedra total alkaloid extract:

[0053] 1.1 Take 1000g of ephedra coarse powder, add 4000mL of 95% ethanol solution containing 0.01mol / L hydrochloric acid; 1 g of ephedra coarse powder;

[0054] 1.2 After adjusting the pH value to 12, add sodium chloride to saturation;

[0055] 1.3 Add 2 times the volume of ethyl acetate for extraction, centrifuge at 3000r / min for 20min, statically separate the layers, take the ethyl acetate layer, repeat the extraction 3 times, and combine the ethyl acetate extracts;

[0056] 1.4 Add concentrated hydrochloric acid to adjust the pH to 2;

[0057] 1.5 Recover the solvent under reduced pressure, and dry it in vacuum to obtain the product.

[0058] 2. Preparation of bitter almond extract:

[0059] 2.1 Take 1000g of bitter almond coarse powder, add 4000mL of 95% ethanol, heat and reflux for extraction for 0.5h, first discard the lower...

Embodiment 2

[0093] 1. Preparation of ephedra total alkaloid extract and bitter almond extract

[0094] 1. Preparation of Ephedra total alkaloid extract:

[0095] 1.1 Take 1000g of ephedra coarse powder, add 4000mL of 95% ethanol solution containing 0.001mol / L hydrochloric acid; soak at room temperature for 12h, heat and reflux extraction for 3 times, each time for 1.5h, filter, and concentrate the filtrate under reduced pressure to the equivalent of 1g per mL Ephedra meal;

[0096] 1.2 After adjusting the pH value to 12, add sodium chloride to saturation;

[0097] 1.3 Add 2 times the volume of ethyl acetate for extraction, centrifuge at 3000r / min for 20min, static layer, take the ethyl acetate layer, repeat the extraction 4 times, and combine the ethyl acetate extract;

[0098] 1.4 Add concentrated hydrochloric acid to adjust the pH to 2;

[0099] 1.5 Recover the solvent under reduced pressure, and dry it in vacuum to obtain the product.

[0100] The ephedra total alkaloid extract was...

Embodiment 3

[0113] 1. Preparation of ephedra total alkaloid extract and bitter almond extract

[0114] 1. Preparation of Ephedra total alkaloid extract:

[0115] 1.1 Take 1000g of ephedra coarse powder, add 6000mL of 95% ethanol solution containing 0.01mol / L hydrochloric acid; soak at room temperature for 12h, heat and reflux extraction 3 times, each time for 1.5h, filter, and concentrate the filtrate under reduced pressure to the equivalent of 1g per mL Ephedra meal;

[0116] 1.2 After adjusting the pH value to 12, add sodium chloride to saturation;

[0117] 1.3 Add 4 times the volume of ethyl acetate for extraction, centrifuge at 3000r / min for 20min, static layer, take the ethyl acetate layer, repeat the extraction 3 times, and combine the ethyl acetate extract;

[0118] 1.4 Add concentrated hydrochloric acid to adjust the pH to 2;

[0119] 1.5 Recover the solvent under reduced pressure, and dry it in vacuum to obtain the product.

[0120] The ephedra total alkaloid extract was anal...

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Abstract

The invention relates to a medical substance, in particular to a medicine for relieving cough and asthma which comprises active ingredients and pharmaceutically acceptable auxiliary material. The active ingredients comprises the following traditional Chinese herb extracts: 80-190 part by weight of ephedra total alkaloid extracts, 200-400 part by weight of bitter almond extracts and 20-160 part by weight of glycyrrhizic acid extracts; wherein, the content of the ephedra total alkaloid in the ephedra total alkaloid extracts extracted from ephedra is 50%-95%, and the content of the amarogentin in the bitter almond extracts extracted from bitter almond is 50% to 93%. The medicine for relieving cough and asthma comprises traditional Chinese herb extracts of ephedra, almond and liquorice. Compared with traditional san'ao soup, the active ingredients in the medicine are concentrated, the dose of the medicine is obvious lower, and the effect of the medicine is better than the medicine effect of the sanao soup.

Description

technical field [0001] The invention relates to a medical preparation, in particular to a Chinese patent medicine using traditional Chinese medicine as a raw material. Background technique [0002] Cough and asthma are clinically common and frequently-occurring diseases, especially cough and asthma, which are one of the common chronic diseases in the world. There are more than 150 million cough and asthma patients in the world. In the past two decades, the incidence rate in the world has been gradually increasing, and it is of great significance to study its treatment. [0003] At present, the treatment of cough and asthma is mainly based on western medicine. The chemical drugs for cough and asthma include adrenal receptor agonists, anti-allergic drugs, theophylline drugs, glucocorticoids, etc. All of the above drugs have certain adverse reactions, and Long-term use will produce tolerance and reduce the curative effect. Traditional Chinese medicine compound preparations ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/736A61P11/14A61P11/06A61K31/704
Inventor 谭晓梅罗佳波
Owner SOUTHERN MEDICAL UNIVERSITY
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