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Medicament for treating infantile enuresis, and preparation method and quality detection method thereof

A technology of enuresis and drugs for children, which is applied in drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., and can solve the problems of meclofenoxate research data, lack of use, danger, etc.

Active Publication Date: 2011-05-11
SHANGHAI CHILDRENS HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Western medicine treatment includes tricyclic antidepressants (imipramine hydrochloride), meclofenate and desmopressin acetate (Desmopressin, DDAVP), etc. Imipramine hydrochloride is no longer used in the treatment of enuresis in children due to its serious adverse reactions ; The relevant research data of meclofenoxate are few, and further studies are needed to explore its clinical effect; although DDAVP has a certain curative effect, it is expensive and not accepted by the majority of patients. In addition, DDAVP is applied to patients with simple bedwetting, because it is difficult to grasp some indications, and there is still a certain risk

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1: drug preparation

[0037] 6 parts of mulberry octopus, 6 parts of raspberry, 6 parts of Codonopsis pilosula, 6 parts of Atractylodes macrocephala,

[0038] 6 parts of rehmannia, 4 parts of angelica, 6 parts of South sea cucumber, 20 parts of raw oyster,

[0039] 6 parts of chuanxiong, 3 parts of polygala, 6 parts of calamus, 1 part of white cardamom,

[0040] Agrimony 6 parts, Schisandra 1 part, white peony 6 parts, licorice 2 parts.

[0041] Take the sixteen flavors of traditional Chinese medicine in the prescription, soak the oysters in water to fully moisten them, add water to immerse them, decoct for 15 minutes, filter, and use the filtrate for later use. wet. The amount of water to be added is 2-4 cm over the medicinal surface, decocted twice, the first time is 1.5 hours, the second time is 1 hour, the decoction is filtered, combined and left for more than 12 hours, the supernatant is concentrated to about 900ml at night, and the above Combine ...

Embodiment 2

[0042] Example 2: Differentiation methods in drug quality testing

[0043] A: Take 20ml of the medicine of Example 1, shake and extract 2 times with ethyl acetate, 30ml each time, combine the ethyl acetate solution, evaporate to dryness, add 1ml of ethyl acetate to the residue to dissolve, and use it as the test solution. Take another 0.2 g of Angelica reference medicinal material, add 20 ml of ethyl acetate, ultrasonically treat for 15 minutes, filter, evaporate the filtrate to dryness, add 10 ml of ethyl acetate to dissolve the residue, and use it as the reference medicinal material solution. Take 10ul of the test solution and 2ul of the reference medicinal material solution according to thin-layer chromatography, respectively spot on the same silica gel G thin-layer plate, use n-hexane-ethyl acetate (9:1) as the developer, develop, take out, and dry in the air , set the UV lamp (365nm) to view. In the chromatogram of the test product; at the position corresponding ...

Embodiment 3

[0045] Example 3: clinical research

[0046] 1. Diagnostic criteria

[0047] (1) Diagnostic criteria of traditional Chinese medicine (based on the State Administration of Traditional Chinese Medicine "Diagnosis and Curative Effect Standards of Traditional Chinese Medicine Syndrome" in 1994)

[0048] ① deep sleep, difficult to wake up, bed-wetting occurs every night or every few days, or even several times in one night.

[0049] ②The age of onset is over 5 years old.

[0050] ③ Urinary routine and urine culture mostly showed no abnormalities.

[0051] ④ X-ray film examination, some children can be found to have occult spina bifida, and X-ray urography shows its structural abnormality.

[0052] (2) Western medicine diagnostic criteria (based on the 1998 International Pediatric Urinary Continence Association standards)

[0053] ①Normal urination occurs at an inappropriate or socially unacceptable time and place, that is, children with enuresis urinate on the bed during sle...

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PUM

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Abstract

The invention belongs to the field of traditional Chinese medicines, and discloses a medicament for treating infantile enuresis, and a preparation method and a quality detection method thereof. According to the theory of traditional Chinese medical science, the preparation method comprises the following steps of: proportioning mantis egg-case, raspberry, szechuan tangshen root, largehead atractylodes rhizome, rehmannia root, Chinese angelica, south sea cucumber, raw oyster shell, smilax tuber, thinleaf milkwort root-bark, grassleaf sweelflag rhizome, round cardamom fruit, hairyvein agrimonia herb and bud, Chinese magnoliavine fruit, white paeony root and liquoric root according to a certain weight ratio; and immersing, decocting, filtering and concentrating to prepare a compound mixture. The medicament has the effects of tonifying spleen, nourishing kidney, replenishing qi and blood, coordinating water and fire and the like, and is used for treating the infantile enuresis.

Description

technical field [0001] The invention relates to a medicine for treating enuresis in children, a preparation method and a quality detection method thereof, and belongs to the field of traditional Chinese medicines. Background technique [0002] Enuresis in children is a common disease in childhood. The incidence rate is high. According to statistics, the incidence rate is 15%-20% at the age of 5-7. Although about 15% of children recover spontaneously every year, there are still 2%-4% of children who still have symptoms when they are 15 years old or even adults. disappear. Enuresis in children is very harmful, causing inconvenience to children's life, and seriously affecting the growth of children's physical and mental health, making children lack self-confidence, easy to be anxious, and afraid of collective life, which in turn affects their academic performance and intellectual development. Or even lead to paranoia, violent tendencies and suicidal tendencies. Some studies ...

Claims

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Application Information

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IPC IPC(8): A61K36/9064G01N30/90A61P13/00A61K35/56A61K35/64A61K35/618
Inventor 李江奇胡斯王申东沈阳刘兆康张武标
Owner SHANGHAI CHILDRENS HOSPITAL
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