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New application of antineoplastic constituent compound in solanum nigrum

A composition and non-active technology, applied in the direction of organic active ingredients, antineoplastic drugs, medical preparations containing active ingredients, etc., can solve the problems of no prompting and undisclosed application of solanine, and achieve low toxicity and reduce Effect on Relative Tumor Proliferation Rate

Active Publication Date: 2011-05-18
HAINAN SIMCERE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The application does not disclose the application of solasonine and solamargine compositions in the treatment of liver cancer drugs, nor give relevant hints

Method used

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  • New application of antineoplastic constituent compound in solanum nigrum
  • New application of antineoplastic constituent compound in solanum nigrum
  • New application of antineoplastic constituent compound in solanum nigrum

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1 injection preparation

[0015] Solanine Injection: Take 140 mg of solanine, slowly add 1.5% glacial acetic acid solution to dissolve it to 100 mL, and obtain it.

[0016] Solanine injection: take 140mg of solanine, slowly add 1.5% glacial acetic acid solution to dissolve it and make it reach 100mL.

[0017] Composition injection A (weight ratio 4:1): Take 112 mg of solanine and 28 mg of solanine, and slowly add 1.5% glacial acetic acid solution to dissolve them to 100 mL.

[0018] Composition injection B (weight ratio 7:1): Take 122.5 mg of solanine and 17.5 mg of solanine, and slowly add 1.5% glacial acetic acid solution to dissolve them to 100 mL.

[0019] Composition injection C (weight ratio 4:1): Take 56 mg of solanine and 14 mg of solanine, and slowly add 1.5% glacial acetic acid solution to dissolve them to 100 mL.

[0020] Composition injection D (weight ratio 7:1): Take 60.9 mg of solanine and 8.7 mg of solanine, and slowly add 1.5% glacial aceti...

Embodiment 2

[0023] Example 2 Establishment of HepG2 nude mouse xenograft tumor model

[0024] Recover and amplify HepG2 cells; when sufficient cells are amplified, collect the cells and use serum-free 1640 to make a concentration of 2×10 7 cell / ml cell suspension.

[0025] Select 60 BALB / c-nude nude mice (SPF grade, 5-6 weeks old, male); subcutaneously inoculate the right side of the back of the nude mice, 0.1ml / only, that is, the number of cells inoculated in each nude mouse is 2×10 6 ; Observe tumor appearance and tumor size after inoculation.

Embodiment 3

[0026] Embodiment 3 effect comparison

[0027] 3.1 Grouping: when the tumor grows to a volume of 150mm 3 When left and right, 36 nude mice with similar tumor volume and better shape were selected from 60 nude mice, and divided into 6 groups, 6 mice in each group.

[0028] Group 1: the control group, given 1.5% glacial acetic acid solution, 0.1 ml per 10 grams of body weight, and stopped the administration for four days after every three days of administration, for a total of 3 weeks.

[0029] Group 2: Administer the positive drug—cisplatin injection (concentration: 0.6 mg / ml), intraperitoneally inject 0.1 ml per 10 grams of body weight, once a week, for 3 weeks in total.

[0030] Groups 3 to 6 were given part of the injection prepared in Example 1, 0.1 ml per 10 grams of body weight, and stopped for four days after every three days of administration, for a total of 3 weeks. Group 3 was given solanine injection; group 4 was given solanine injection; group 5 was given composit...

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Abstract

The invention relates to the application of ratio compounds of two simplex components in plant solanum nigrum extracts to preparing medicaments for treating liver cancer.

Description

technical field [0001] The invention relates to the application of a ratio composition of two monomer components in the extract of plant Solanum nigrum, wherein the monomer components are solanine and solanine, respectively, in the preparation of drugs for treating liver cancer. Background technique [0002] Solalum Nigrum L. is an annual herbaceous plant of the genus Solanum, which grows in most provinces and regions in China. The whole herb is used for medicine, cold in nature, bitter, pungent and slightly sweet, slightly poisonous, and returns to the lung and bladder meridian. It can dissipate stasis and reduce swelling, clear heat and detoxify, and has the effect of inhibiting cancer cells. It is commonly used to treat pain, swelling, tumors, etc. In addition, nightshade has a certain therapeutic effect, so it has good medicinal value. Plants are rich in steroidal alkaloids. These steroidal alkaloids exist in the stems, leaves, roots, and fruits of Solanum nigrum in th...

Claims

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Application Information

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IPC IPC(8): A61K31/706A61P35/00
Inventor 陈荣冯林李海岛周娟
Owner HAINAN SIMCERE PHARMA CO LTD
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