Quality control method for Chinese medicine preparation Xuefuzhuyu capsule

Abstract

The invention belongs to the technical field of Chinese patent medicines, and relates to a quality control method for a Chinese medicine preparation Xuefuzhuyu capsule prepared from traditional Chinese medicinal materials. In the quality control method, citrus trifoliata is utilized as a comparison medicinal material, naringin is used as a comparison product, Chinese angelica and szechwan lovage rhizome are used as comparison medicinal materials, Chinese thorowax root is used as a comparison medicinal material, liquorice is used as a comparison medicinal material, and whether the formula of the Xuefuzhuyu capsule contains citrus trifoliata, Chinese angelica szechwan lovage rhizome, Chinese thorowax root and liquorice is identified by means of thin-layer chromatography; and amygdalin is used as a comparison product, and whether peach seed is contained in the Xuefuzhuyu capsule is identified by means of high performance liquid chromatography. By utilizing the quality control method provided by the invention, fraudulent medicaments and inferior medicaments can be identified more accurately, so as to improve the safety in use. By utilizing an inspection method for determining the content of paeoniflorin used as a quantitative indicator by means of high performance liquid chromatography, the controllability of the quality standards of the Xuefuzhuyu capsule is improved, and the inherent quality and curative effect of products are further ensured; and the revised quality standards are improved, and the quality control of the Xuefuzhuyu capsule is improved.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and relates to a quality control method for a traditional Chinese medicine preparation Xuefu Zhuyu Capsules prepared by using traditional Chinese medicinal materials as raw materials. Background technique [0002] Xuefu Zhuyu Capsule is a classic Chinese patent medicine. 3 -B-3049-98 records the formulation and quality standards: [0003] prescription: [0004] Peach kernels (fried) Angelica Fructus Citrus (fried bran) Chuanxiong [0005] Bupleurum safflower Achyranthes red peony [0006] Rehmannia bellflower Licorice [0007] Preparation method: extract 1-3 times with water for eleven medicinals such as Angelica sinensis, 6-10 times the water consumption, 0.5-1.5h each time, filter, collect the filtrate, and concentrate under reduced pressure to a relative density of 1.07-1.35 (60 -70°C), leave it to cool at room temperature, add ethanol to make the alcohol content 60-...

AI Technical Summary

Problems solved by technology

[0009] At present, there are many product literatures with similar prescriptions and similar effects to Xuefu Zhuyu Capsules, but there are no product literatures with the same prescriptions and the same efficacy. However, in the existing quality control methods of Xuefu Zhuyu Capsules issued by the Ministry of Health, Under the item of identification, there is only microscopic identification, TLC identification of the medicinal materials of Fructus Fructus Fructus, and only one component of paeoniflorin is quantified under the item of content determination

For the compound Xuefu Zhuyu Capsules composed of eleven medicinal materials, only the qualitative identification of one medicinal material and the content determination of a single index component are used as its quality control method, which is not specific, has large limitations, and cannot fully reflect the product quality. Uniformity and stability, it is difficult to control the quality of Xuefu Zhuyu Capsules

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