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Novel GLP-1 (glucagon-like peptide-1) derivative

A technology of GLP-1 and derivatives, which is applied in the field of bioengineering, can solve the problem of inactivation of the second amino acid, achieve good clinical application value, mature technology, and prolong the effect of drug effect

Inactive Publication Date: 2011-06-29
EAST CHINA NORMAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The GLP-1 derivatives provided by this invention patent application have the following disadvantages, such as: the second amino acid is still easily degraded by DPPIV and loses its activity in vivo

Method used

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  • Novel GLP-1 (glucagon-like peptide-1) derivative
  • Novel GLP-1 (glucagon-like peptide-1) derivative
  • Novel GLP-1 (glucagon-like peptide-1) derivative

Examples

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Embodiment 1

[0027] Example 1 The GLP-1 derivative proposed in the applicant's prior invention patent application (application number: 200610024355.X; invention name: a human glucagon-like peptide-1 derivative and its preparation and application) The amino acid sequence of , such as Seq ID No.2, wherein Xaa32=Cys.

Embodiment 2

[0028] Example 2 The amino acid sequence of the GLP-1 derivative of the present invention, such as Seq ID No.3, wherein Xaa2=Gly, Xaa32=Cys.

Embodiment 3

[0029] Example 3 The amino acid sequence of the GLP-1 derivative of the present invention, such as Seq ID No.3, wherein Xaa2=Thr, Xaa32=Cys.

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Abstract

The invention discloses a novel GLP-1 (glucagon-like peptide-1) derivative. The molecular structural formula of the derivative is cGLP-1(7-38), namely, Seq ID No.3, wherein, Xaa2 is any one of amino acids such as Gly, Thr and Val. The derivative is prepared by a recombinant DNA (deoxyribonucleic acid) technology and has a half-life period which is longer than that of GLP-1; and the derivative is suitable for serving as an active ingredient for preparing a medicament for treating diabetes.

Description

technical field [0001] The invention relates to the technical field of bioengineering, and relates to a GLP-1 derivative with GLP-1 activity and its preparation and application. Background technique [0002] Diabetes is a worldwide disease with rapid development and great harm to human beings. In 2007, about 246 million people worldwide suffered from diabetes, and it is estimated that by 2025, the number of diabetic patients worldwide will increase to 380 million. According to a survey conducted by the Chinese Medical Association in 2007, the prevalence of diabetes among people over 20 years old in cities and towns in my country is about 10%, and the age of patients is also showing a trend of younger age. Among diabetic patients, nearly 90% of them are type 2 diabetes, which cannot be treated with insulin alone. With the rapid increase of diabetic patients, the cost of treatment and related complications has also increased dramatically, which has brought huge labor losses ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/605C12N15/16C12N15/70A61K38/26A61P3/10
Inventor 黄静汪洋杨利蒋子威包志宏吴自荣
Owner EAST CHINA NORMAL UNIV