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Placebo for coronary heart disease

A technology of coronary heart disease and placebo, applied in the field of placebo, can solve the problems of pharmacological activity of irreversible diseases, and achieve the effect of not easily breaking the blindness

Inactive Publication Date: 2011-07-27
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

Therefore, the selection of raw materials for making placebos should be extremely cautious, and they should not have pharmacological activity on the diseases treated by the clinical trial.

Method used

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  • Placebo for coronary heart disease
  • Placebo for coronary heart disease
  • Placebo for coronary heart disease

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Experimental program
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Effect test

Embodiment Construction

[0015] Coronary heart disease formula placebo, its ratio is: maltodextrin 100kg, caramel pigment 2kg, lemon yellow pigment 0.35kg, sunset yellow pigment 0.04kg, sugar octaacetate 0.04kg, orange essence 0.03kg, rugosa 0.045kg Essence, 0.75kg of beta-cyclodextrin, 3kg of "Coronavirus Prescription".

[0016] Its preparation method is as follows:

[0017] Take 0.75kg of beta cyclodextrin in the prescription, add 3kg of water to dissolve, then add 0.03kg of orange essence and 0.045kg of Huoxiang essence, mix evenly, put it in a colloid mill and grind for 10 minutes to obtain the essence inclusion complex;

[0018] Take 100kg of maltodextrin, 2kg of caramel pigment, 0.35kg of lemon yellow pigment, 0.04kg of sunset yellow pigment, 0.04kg of sugar octaacetate, add 300kg of water to dissolve evenly, then add the above essence inclusion compound and mix evenly, and spray the mixture dry powder;

[0019] After spraying the dry powder through a 100-mesh sieve, add 3 kg of the "Corona He...

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Abstract

The invention discloses placebo for coronary heart disease and a preparation method thereof. The placebo contains malto dextrin, caramel pigment, sunset yellow pigment, tartrazine, sucrose octaacetate, tangerine essence, agastache rugosus essence, Beta-cyclodextrin and non-decoction coronary heart disease particles. The preparation method comprises the following steps: taking the Beta-cyclodextrin and adding water for dissolving, then adding the tangerine essence and the agastache rugosus essence and mixing uniformly, arranging the mixture into a colloid mill for milling ten minutes so as to obtain essence compound; taking the malto dextrin, the caramel pigment, the sunset yellow pigment, the tartrazine, and the sucrose octaacetate and adding water for dissolving, then adding the essence compound in the mixture and mixing uniformly, spraying and drying the mixture liquid so as to obtain spray drying powder; and sieving the spray drying powder by a sieve with 100 meshes, and mixing the spray drying powder with the non-decoction coronary heart particles uniformly, mixing the obtained drying powder is mixed, granulating by a drying method, packaging and then obtaining the placebo. The placebo for the coronary heart disease is more similar to the non-decoction coronary heart particles in smell, taste and color, is not easy to be taken as a placebo by a tester, so that blindness breaking of a double-blind experiment can be guaranteed to be difficult.

Description

Technical field [0001] The present invention involves a placebo, which specializes in a placebo for the treatment of Chinese medicine preparations for the treatment of coronary heart disease. Background technique [0002] As the drug clinical trial management specification (GCP) is continuously deepened in the clinical research of Chinese medicine, the clinical trial design of traditional Chinese medicine follows the four principles of random, control, blind method, and repeated. [0003] The placebo refers to a preparation of neutralized and non -toxic side effects, similar to the treatment of therapeutic medicine.Therefore, the selection of raw materials for the production of placebo should be particularly cautious, and it cannot have a pharmacological activity effect on the diseases treated in the clinical trial. [0004] In the process of implementing the principle of blindness, the placebo request as a controller is consistent with the treatment of the treatment drugs in app...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00
Inventor 阮新民王云飞吴焕林李晓庆穆启运欧爱华曹炳君朱文荣
Owner GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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