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A technology of phenylpropanoid glycoside and structural formula, which is applied in the field of extracting active ingredients, and can solve the problems of limited clinical application, adverse reactions of western medicine, and high price.
Inactive Publication Date: 2011-09-28
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY +1
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However, due to the adverse reactions and high prices of western medicines, clinical application is limited, so it is of great significance to find effective anti-myocardial fibrosis drugs in the field of traditional Chinese medicine.
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[0048] Inhibitory Effect of Oral Phenylpropanol Glycoside on Myocardial Fibrosis Induced by Isoproterenol in Rats
[0049] 40 Waster rats were provided by Bikai Experimental Animal Co., Ltd., and were adaptively fed for 1 week before the experiment in the Animal Institute of the Second Military Medical University. After arriving at the laboratory, the purchased rats were randomly divided into 4 groups, including the normal control group, the model group, the phenylpropanoid group and the positive control enalapril group, and the phenylpropanoid group and the enalapril group The dose of 10 mg / kg per day was administered by intragastric administration continuously for 13 days, and the control group and the model group were given equal volumes of normal saline. Except for the normal control group, the rats in the other groups were subcutaneously injected with isoproterenol in the back, the first dose was 20 mg / kg, the dose on the second day was 10 mg / kg, the dose on the third day...
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Abstract
The invention provides an application of a phenylpropanoid glycosides to prepare medicament for inhibiting cardiac muscle fibration. Rats are randomly divided into a model group, a phenylpropanoid glycosides group, a positive contrast group and a normal contrast group. In a test, isoproterenol is injected into the back to generate a rat cardiac muscle fibration model; the normal contrast group and the model group are fed with normal saline, and other groups are drugged. Results show that in the phenylpropanoid glycosides group and the positive contrast group, heart fibroblast hyperplasia is reduced, cardiac muscle fibration is mitigated obviously, and hydroxyproline content shows no obvious change compared with the contrast group.
Description
technical field [0001] The invention relates to extracting active ingredients from Radix Scrophulariae, more specifically to phenylpropanoid glycosides extracted from Radix Scrophulariae and their use for inhibiting myocardial fibrosis. Background technique [0002] Scrophulariaceae is a commonly used traditional Chinese medicine, which was first recorded in "Shen Nong's Materia Medica". Scrophulariaceae is sweet, bitter, salty, cool, and has the functions of nourishing yin, reducing fire, eliminating annoyance, and detoxifying. It can cure fever, polydipsia, spots, bone steaming and labor heat, restless sleep at night, spontaneous sweating, sore throat, etc. Scrophulariaceae, a traditional Chinese medicine, is mainly the root of Scrophulariaceae, a plant of the genus Scrophulariae in the family Scrophularaceae. Scrophulariaceae is a unique plant in my country, distributed in Zhejiang, Anhui, Jiangsu, Fujian, Jiangxi and other places. [0003] The research on the chemical...
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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7028C07H15/18C07H1/08A61P9/04
Inventor 黄才国李医明魏善建王瑞
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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