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A drug for the treatment of benign prostatic hyperplasia

A technology of benign prostatic hyperplasia and seeds, which is applied in the field of medicine to achieve a clear effect of medicine

Active Publication Date: 2011-11-30
淮安首考科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, there is still a lack of an effective drug for the treatment of benign prostatic hyperplasia.

Method used

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  • A drug for the treatment of benign prostatic hyperplasia
  • A drug for the treatment of benign prostatic hyperplasia
  • A drug for the treatment of benign prostatic hyperplasia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Take an appropriate amount of barley seeds, heat and reflux with 5 times the amount of distilled water, extract three times, each extraction time is 1.5 hours, combine the three extracts, filter with a 150-mesh double-layer filter cloth, heat and concentrate the filtrate to 1 / 3 of the original volume; 4 times of ethanol was added to the concentrated extract under stirring, and after standing still for 12 hours, the precipitate was collected to obtain the crude polysaccharide of barley cabbage. Add distilled water to the crude polysaccharide precipitate to dissolve it, make it fully redissolved, add trichloroacetic acid to a concentration of 1-10%, let it stand for 3 hours after stirring, heat and concentrate the solution to 1 / 3 of the original volume, and concentrate the extract under stirring 4 times of ethanol was added to it, and after standing for 12 hours, the precipitate was collected. The precipitate was washed 3 times with an appropriate amount of absolute ethan...

Embodiment 2

[0022] Take an appropriate amount of barley seeds, heat and reflux with 5 times the amount of distilled water, extract three times, each extraction time is 1.5 hours, combine the three extracts, filter with a 150-mesh double-layer filter cloth, heat and concentrate the filtrate to 1 / 3 of the original volume; 4 times of ethanol was added to the concentrated extract under stirring, and after standing still for 12 hours, the precipitate was collected to obtain the crude polysaccharide of barley cabbage. Add distilled water to the crude polysaccharide precipitate to dissolve it, make it fully redissolved, adjust the pH to 7, add 3% trypsin, soak at 65°C for 1.5h, then add 2.5% papain, soak at 55°C for 1.5h. Ultrafiltration with a membrane filter with a molecular weight cut-off of 10,000. Collect the retentate, add 500mL of 75% ethanol, let it stand for 12h, and collect the precipitate. The precipitate was washed 3 times with an appropriate amount of absolute ethanol, and dried to...

Embodiment 3

[0025] Take an appropriate amount of barley seeds, add 5 times the amount of distilled water, and carry out microwave extraction. The microwave power is 600w, extract twice, and each extraction time is 10min. to 1 / 3 of the original volume; add 4 times of ethanol to the concentrated extract under stirring, and after standing for 12 hours, collect the precipitate to obtain the crude polysaccharide of barley cabbage. Add distilled water to the crude polysaccharide precipitate to dissolve, heat to 70°C to fully redissolve, heat and concentrate the solution to 1 / 3 of the original volume, add 4 times of ethanol to the concentrated extract under stirring, let it stand for 12 hours, and collect precipitation. The precipitate was washed 3 times with an appropriate amount of absolute ethanol, and dried to obtain the refined polysaccharide of barley cabbage. The refined polysaccharide of barley lettuce can be further prepared into various pharmaceutically acceptable compositions and var...

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Abstract

The invention belongs to the technical field of medicine, and particularly relates to a medicament for treating prostatic hyperplasia. Major active ingredients are polysaccharides extracted from Vaccaria segetalis (Neck.) Garcke serving as caryophyllaceae plants. The polysaccharides are from seeds of the Vaccaria segetalis (Neck.) Garcke. A method for preparing the polysaccharides of the Vaccariasegetalis (Neck.) Garcke and the medicinal composition of the polysaccharides of the Vaccaria segetalis (Neck.) Garcke is simple and effective, and the polysaccharides of the Vaccaria segetalis (Neck.) Garcke and the medicinal composition of the polysaccharides of the Vaccaria segetalis (Neck.) Garcke can be prepared into various common oral formulations of solid, liquid and the like. The medicament is mainly used for treating the prostatic hyperplasia and frequent micturition, urgent urination, odynuria and dysuresia which are caused by the prostatic hyperplasia. Compared with the conventional medicament, the medicament for treating the prostatic hyperplasia is obvious and quick in curative effect, low in relapse rate and stable and controllable in quality, and does not have any toxic orside effect.

Description

1. Technical field [0001] The invention relates to a medicine for treating benign prostatic hyperplasia and a preparation method thereof, belonging to the technical field of medicine. 2. Background technology [0002] Prostatic hyperplasia (benign prostatic hyperplasia, BPH) is the proliferation of cells around the prostatic urethra, the progressive enlargement of the glands, narrowing the urethra, and causing blockage of urine outflow from the bladder. It is a common cause and seriously affects the quality of life of patients. It is a common disease of middle-aged and elderly men, also known as benign prostatic hypertrophy. It ranks second only to urolithiasis among inpatients in urology. The current treatment methods for BPH include surgical treatment and drug treatment. Among them, surgical treatment is quick and effective, but surgery has certain limitations. According to clinical statistics, about 10%-15% of patients have no obvious improvement in symptoms after prosta...

Claims

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Application Information

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IPC IPC(8): A61K36/36A61K31/715C08B37/00A61P13/08A61K131/00
Inventor 张海江王兆凯
Owner 淮安首考科技有限公司
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