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A kind of psyllium extract and its preparation method and application

A technology of psyllium seed extract and extract solution, which can be applied in the direction of drug combination, medical formula, plant raw materials, etc., and can solve the problems of needing family care, patients, family social burden, life unable to take care of themselves, etc., and achieve the effect of good application prospects

Active Publication Date: 2011-11-30
BEIJING COLLAB PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Vascular dementia patients are generally unable to take care of themselves and need family care from time to time, which brings a heavy burden to patients, families and society
At present, there is no report on the method of extracting iridoids and phenylethanol glycosides from Plantaginacea and using them to treat senile dementia

Method used

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  • A kind of psyllium extract and its preparation method and application
  • A kind of psyllium extract and its preparation method and application
  • A kind of psyllium extract and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) Extraction: Psyllium sylvestris crushed, passed through a 20-mesh sieve, weighed 1000g and extracted with ultrasonic, added 70% ethanol at a liquid-solid ratio of 10 times, extracted with ultrasonic (frequency 80KHz) for 30min, repeated extraction 3 times, and filtered, The extracts were combined, ethanol was recovered and concentrated to 1000ml, cooled to room temperature, allowed to stand for 24 hours, centrifuged and filtered to obtain a clear filtrate.

[0027] (2) Refining ①: The above solution to be loaded onto the column is added to the ethanol-treated HP-20 type macroporous resin column at a flow rate of 0.5 BV / h, with water, 10%, 30%, 50% and 75% methanol Sequential gradient washing, HPLC detection, collect the fractions rich in iridoid compounds (water washing and 10% part) and phenethyl alcohol glycosides (30% part), combine, concentrate under reduced pressure, and spray dry to obtain Psyllium Extract. Measured by ultraviolet (UV) method, the content of iri...

Embodiment 2

[0030] (1) Extraction: Psyllium sylvestris are crushed, passed through a 20-mesh sieve, weighed out 1000g, heated to reflux with 70% ethanol, and 70% ethanol is added at a 4 times liquid-to-solid ratio each time, the first reflux is 2 hours, the second And the third reflux for 1 hour. Filter with suction, combine the extracts, recover ethanol and concentrate to 1000ml, cool to room temperature, stand for 24 hours, centrifuge and filter to obtain a clear filtrate.

[0031] (2) Refining①: The above-mentioned filtrate was added to the ethanol-treated AB-8 type macroporous resin column at a flow rate of 1BV / h, and washed with water, 10%, 30% and 75% ethanol successively in gradients, HPLC For detection, the water-washed and 10% ethanol fraction rich in iridoids and the 30% ethanol fraction rich in phenethyl alcohol glycosides are collected, combined, concentrated to an extract, and vacuum dried to obtain a Psyllium extract. Measured by ultraviolet (UV) method, the content of iridoid...

Embodiment 3

[0034] (1) Extraction: Soften the plantago seeds with water vapor, dry, crush, sieving, weigh 1000g of the buried plantago seeds powder, extract with water, add deionized water at a liquid-solid ratio of 40 times, Each extraction is carried out for 2 hours, and the treatment is repeated 3 times. The extracts are filtered, combined, recovered ethanol and concentrated to 1000ml, cooled to room temperature, allowed to stand for 24 hours, centrifuged and filtered to obtain a clear filtrate.

[0035] (2) Refining①: Add the above-mentioned filtrate to a column of ethanol-treated polyamide at a flow rate of 1BV / h, wash with water, 10%, 50%, and 75% ethanol successively in gradients, detect by HPLC, and collect The water-washed and 10% ethanol-eluted fractions containing iridoids, and the 50% ethanol-eluted fractions rich in phenethyl alcohol glycosides are combined, concentrated under reduced pressure, and dried in vacuum to obtain a Psyllium extract. Measured by ultraviolet (UV) method...

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Abstract

The invention relates to the technical field of natural medicines, in particular to plantain seed extract, a preparation method and application thereof. In the plantain seed extract, the main effective ingredients are iridoids and phenylethanoid glycosides which are vegetable extracts, wherein the vegetable extracts are extracted from the vegetable plantain seed with a solvent; and then refined and purified by a chromatographic process. The invention also provides the applications of the plantain seed extract in preparation of the medicines for preventing the vascular dementia.

Description

Technical field [0001] The invention belongs to the technical field of natural medicine. Specifically, it relates to a plantago seed extract and its preparation method and use. Background technique [0002] With the aging of the world's population, many diseases related to aging such as neurodegenerative diseases are seriously affecting people's health and quality of life. Vascular dementia (Vascular Dementia, VD) is a dementia syndrome caused by vascular disease. Due to the impairment of memory and other cognitive functions, dementia patients can weaken or lose their social activities and basic daily life. This is not only for the patient. Mental and physical causes great pain, and also a great burden on the family and society. Modern medical research believes that the occurrence of vascular dementia is often closely related to cortical lesions, especially left cortical ischemia and ischemic changes in the thalamus and hippocampus. In addition, bilateral and multiple cerebral...

Claims

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Application Information

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IPC IPC(8): A61K36/68A61P25/28A61K131/00
Inventor 王珂赵大龙陈明霞王振辉
Owner BEIJING COLLAB PHARMA
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