Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Methods and compositions for diagnosis and prognosis of renal injury and renal failure

A technology for kidney injury markers and acute renal failure, applied in biochemical equipment and methods, disease diagnosis, biological testing, etc., can solve problems such as inability to distinguish types or locations

Inactive Publication Date: 2011-12-07
ASTUTE MEDICAL
View PDF18 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because serum creatinine is a marker of filtration rate, it is not possible to differentiate the etiology of AKI (prorenal, intrarenal, metanephric obstruction, atherosclerotic embolism, etc.) or the type or location of intrarenal disease (eg, tubular, renal glomerulus or renal space)

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Methods and compositions for diagnosis and prognosis of renal injury and renal failure
  • Methods and compositions for diagnosis and prognosis of renal injury and renal failure
  • Methods and compositions for diagnosis and prognosis of renal injury and renal failure

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0161] Preparation of solid phase and detectably labeled conjugates typically involves the use of chemical crosslinkers. Crosslinkers include at least two reactive groups, and can be classified into homofunctional crosslinkers (comprising the same reactive groups) and heterofunctional crosslinkers (comprising non-identical reactive groups). Biologically functional cross-linkers that conjugate non-specifically via amines, thiols, or reactions are available from a number of commercial sources. Maleimides, alkyl and aryl halides, and α-haloacyls react with thiols to form thioether linkages, while pyridyl disulfides react with sulfhydryls to form mixed disulfides. The pyridyl disulfide product is cleavable. Imidates are also very useful for protein-protein crosslinks. A variety of xenobiofunctional crosslinkers, each incorporating different features for successful conjugation, are commercially available.

[0162]In some aspects, the invention provides kits for analyzing said ki...

Embodiment 1

[0200] Example 1: Sample collection of contrast agent-induced nephropathy

[0201] The purpose of this sample collection study was to collect plasma and urine samples as well as clinical data from patients before and after receiving intravascular contrast media. Approximately 250 adults underwent a radioimaging / angiography procedure involving intravascular administration of iodinated contrast medium. In order to participate in this study, each patient must meet the following selection criteria and not meet the following exclusion criteria:

[0202] selection criteria

[0203] Men and women 18 years of age or older;

[0204] Have undergone a radiographic / angiographic procedure (e.g., CT scan or coronary intervention), including intravascular administration of contrast media;

[0205] Admission to the hospital is expected to be at least 48 hours after contrast administration.

[0206] Can and will provide written informed consent for study participation and adherence to all ...

Embodiment 2

[0217] Embodiment 2: cardiac surgery sample collection

[0218] The purpose of this sample collection study was to collect plasma and urine samples as well as clinical data from patients before and after undergoing cardiovascular surgery, a procedure known to be potentially damaging to renal function. About 900 adults who underwent the procedure participated. In order to participate in the study, each patient must meet all of the following selection criteria and none of the exclusion criteria:

[0219] selection criteria

[0220] Men and women 18 years of age or older;

[0221] have undergone cardiovascular surgery;

[0222] A kidney replacement risk score of at least 2 on the Toronto / Ottawa Predictive Risk Index (Wijeysundera et al., JAMA 297:1801-9, 2007); and

[0223] Can and will provide written informed consent for study participation and adherence to all study steps.

[0224] exclusion criteria

[0225] pregnant;

[0226] previous kidney transplant;

[0227] Acut...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Sensitivityaaaaaaaaaa
Login to View More

Abstract

The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of Epidermal growth factor, Complement C3, Interleukin-4, Interleukin- 1 alpha, Tubulointerstitial nephritis antigen, Transforming growth factor beta-1, Bone morphogenetic protein 7, Osteopontin, Netrin-1, and Growth-regulated alpha protein as diagnostic and prognostic biomarkers in renal injuries.

Description

[0001] This invention claims U.S. Provisional Patent Application 61 / 117,137, filed November 22, 2008, U.S. Provisional Patent Application 61 / 117,142, filed November 22, 2008, Patent Application 61 / 117,147, 2008, filed November 22, 2008 U.S. Provisional Patent Application 61 / 117,159 filed November 22, 2008 U.S. Provisional Patent Application 61 / 117,164 filed November 22, 2008 U.S. Provisional Patent Application 61 / 117,165 filed November 22, 2008 U.S. Provisional Patent Application 61 / 117,166 filed on November 22, 2008, U.S. Provisional Patent Application 61 / 117,170, filed on November 22, 2008, U.S. Provisional Patent Application 61 / 117,171, filed on November 22, 2008, and Priority to U.S. Provisional Patent Application 61 / 117,174, filed on the 22nd, the entire contents of each of the above-mentioned U.S. patent applications, including all tables, drawings and claims, are hereby incorporated herein by reference. Background technique [0002] The background of the present inventi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68
CPCG01N33/6893C12Q2600/158G01N2800/347C12Q1/6883G01N33/53
Inventor J·安德贝里J·格雷P·麦克弗森K·中村
Owner ASTUTE MEDICAL
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com