Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of triclosan as synergist of antifungal agent fluconazole

A technology of triclosan and fluconazole, which can be used in antifungal agents, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve problems such as drug resistance growth

Inactive Publication Date: 2013-04-10
JILIN UNIV
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, resistance to azoles in clinically infectious fungi is increasing, due to the fact that azoles are bacteriostatic rather than fungicides

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of triclosan as synergist of antifungal agent fluconazole
  • Application of triclosan as synergist of antifungal agent fluconazole
  • Application of triclosan as synergist of antifungal agent fluconazole

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0013] Reference literature (National committee for clinical laboratory standards. Reference method for broth dilution antifungal susceptibility testing of yeast; Approved Standard M27-A. Lancaster Avenue, Villanova. Pennsylvania: CLSI, 1997.1-12); (Odds F C, Synergy, and what the Chequerboard puts between them, J Antimicrob Chemother (2003) 52, 1); (Meletiadis J etc, In vitro drug interaction modeling of combinations of azoles with terbinafine against clinical Scedosporium prolifican isolates, Antimicrob Agents Chemother. GM etc, Antimicrobial combination. In: Lorian V, editor. Antibiotics in Laboratory Medicine, 4th ed. Baltimore, MD: The Williams and Wilkins Co. (1996) 330-96) and (Quan Hetc, Potent In Vitro Synergism of Fluconazole and Berberine Chloride againstClinical Isolates of Candida albicans Resistant to Fluconazole, Antimicrob Agents Chemother (2006) 50, 1096-99.) method for drug susceptibility experiments and synergistic experiments, the specific operations are as ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
Login to View More

Abstract

The invention provides a novel application of triclosan as a synergist of an antifungal agent fluconazole, wherein fungi are Candida albicans. Through the standard microdilution method drug susceptibility tests recommended by CLSI (Clinical Laboratory and Standards Institute), in combination with checkerboard microdilution method, time-kill curve, in vitro agar diffusion tests and other series methods, the study evaluates the in vitro sensitivity of triclosan to clinically-isolated drug-resistant Candida albicans, and meanwhile evaluates the in vitro synergetic action of triclosan and fluconazole against clinically drug-resistant fungi.

Description

technical field [0001] The invention relates to the application of triclosan and fluconazole in combination to enhance the antifungal effect of fluconazole. Background technique [0002] At present, it is believed that there are more than 300 kinds of fungi that harm humans and cause diseases. In the past two decades, fungal infections that have seriously endangered human life and health have been increasing both in terms of incidence and types of infections, especially in immunosuppressed patients. Among human fungal infections, the most important opportunistic pathogen is Candida albicans (C. albicans), which can cause from chronic skin infections to life-threatening systemic fungal infections. Pathogenic fungi not only have the general characteristics of fungi, but also from the perspective of medical microbiology, they are usually a type of fungi that can invade the human body and cause diseases in superficial and deep tissues. In addition, some fungi can also stimulat...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4196A61K31/085A61P31/10
Inventor 于录邓旭明郭娜金晶梁俊超李蕾
Owner JILIN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com